Literature DB >> 17107055

Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells.

Chengfeng Xia1, Dapeng Zhou, Chengwen Liu, Yanyan Lou, Qingjia Yao, Wenpeng Zhang, Peng George Wang.   

Abstract

Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to alpha-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3. [structure: see text].

Entities:  

Mesh:

Substances:

Year:  2006        PMID: 17107055     DOI: 10.1021/ol062199b

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.

Authors:  Dale Christiansen; Julie Milland; Effie Mouhtouris; Hilary Vaughan; Daniel G Pellicci; Malcolm J McConville; Dale I Godfrey; Mauro S Sandrin
Journal:  PLoS Biol       Date:  2008-07-15       Impact factor: 8.029

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.