| Literature DB >> 17107047 |
Toyonobu Usuki1, Koji Nakanishi, George A Ellestad.
Abstract
In the presence of thiols, the ten-membered-ring enediyne calicheamicin gamma1I generates a p-benzyne biradical that initiates oxidative cleavage of double-stranded DNA. Application of spin-trapping has successfully provided ESR and mass spectroscopic evidence for the formation of the monoadducts with phenyl tert-butyl nitrone (PBN). [reaction: see text].Entities:
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Year: 2006 PMID： 17107047 DOI： 10.1021/ol062061t
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005