| Literature DB >> 17107010 |
Joohoon Kim1, Jinseok Heo, Richard M Crooks.
Abstract
We report the factors influencing the capture of DNA by DNA-modified microbeads confined within a microfluidic channel. Quantitative correlation of target capture efficiency to probe surface concentration, solution flow rate, and target concentration are discussed. The results indicate that the microfluidic system exhibits a limit of detection of approximately 10(-10) M (approximately 10(-16) mol) DNA and a selectivity factor of approximately 8 x 10(3). Typical hybridization times are on the order of minutes.Mesh：
Substances：
Year: 2006 PMID： 17107010 DOI： 10.1021/la0616956
Source DB: PubMed Journal: Langmuir ISSN： 0743-7463 Impact factor: 3.882