Literature DB >> 17106256

Cyclin D1 functions in cell migration.

Zhiping Li1, Chenguang Wang, George C Prendergast, Richard G Pestell.   

Abstract

Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.

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Year:  2006        PMID： 17106256     DOI： 10.4161/cc.5.21.3428

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  54 in total

1.  Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex.

Authors:  Louis-Jan Pilaz; Dorothée Patti; Guillaume Marcy; Edouard Ollier; Sabina Pfister; Rodney J Douglas; Marion Betizeau; Elodie Gautier; Veronique Cortay; Nathalie Doerflinger; Henry Kennedy; Colette Dehay
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-03       Impact factor: 11.205

Review 2.  Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors.

Authors:  Nawal Bendris; Bénédicte Lemmers; Jean Marie Blanchard
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

3.  MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling.

Authors:  Vien Khach Lai; Muhammad Ashraf; Shujia Jiang; Khawaja Haider
Journal:  Cell Cycle       Date:  2012-02-15       Impact factor: 4.534

4.  MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion.

Authors:  Qian-Qian Zhang; Hui Xu; Mian-Bo Huang; Li-Ming Ma; Qiao-Juan Huang; Qing Yao; Hui Zhou; Liang-Hu Qu
Journal:  Neuro Oncol       Date:  2012-01-04       Impact factor: 12.300

5.  Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells.

Authors:  Tapasree Roy Sarkar; Shikha Sharan; Jun Wang; Snehalata A Pawar; Carrie A Cantwell; Peter F Johnson; Deborah K Morrison; Ju-Ming Wang; Esta Sterneck
Journal:  Mol Cell Biol       Date:  2011-10-28       Impact factor: 4.272

6.  The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression.

Authors:  Paula Mussnich; Daniela D'Angelo; Vincenza Leone; Carlo Maria Croce; Alfredo Fusco
Journal:  Mol Oncol       Date:  2013-01-17       Impact factor: 6.603

7.  Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence.

Authors:  Wen-Bin Ou; Nan Ni; Rui Zuo; Weihao Zhuang; Meijun Zhu; Anastasios Kyriazoglou; Duolin Wu; Grant Eilers; George D Demetri; Haibo Qiu; Bin Li; Adrian Marino-Enriquez; Jonathan A Fletcher
Journal:  Oncogene       Date:  2019-08-01       Impact factor: 9.867

8.  Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.

Authors:  Anke Doller; Kai Schlepckow; Harald Schwalbe; Josef Pfeilschifter; Wolfgang Eberhardt
Journal:  Mol Cell Biol       Date:  2010-01-19       Impact factor: 4.272

9.  Intratumoral delivery of shRNA targeting cyclin D1 attenuates pancreatic cancer growth.

Authors:  S J Deharvengt; J R Gunn; S B Pickett; M Korc
Journal:  Cancer Gene Ther       Date:  2009-10-23       Impact factor: 5.987

10.  Systematic validation of predicted microRNAs for cyclin D1.

Authors:  Qiong Jiang; Ming-Guang Feng; Yin-Yuan Mo
Journal:  BMC Cancer       Date:  2009-06-18       Impact factor: 4.430
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