Literature DB >> 1710579

Molecular cloning and sequence analysis of cDNA encoding delta 4-3-ketosteroid 5 beta-reductase of rat liver.

Y Onishi1, M Noshiro, T Shimosato, K Okuda.   

Abstract

A cDNA clone encoding delta 4-3-ketosteroid 5 beta-reductase was isolated from rat liver cDNA libraries using antibodies specific for the enzyme and oligonucleotides as probes. The cDNA contained 981-base pair open reading frame encoding 327 amino acid residues (Mr 37,376) and an unusually long 3'-untranslated region rich in AT sequence in the total length of 3189 base pairs. The predicted amino acid sequence contains the sequences similar to the putative NADPH- and steroid-binding regions.

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Year:  1991        PMID： 1710579     DOI： 10.1016/0014-5793(91)80591-p

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function.

Authors:  Rebekka Mindnich; Jason E Drury; Trevor M Penning
Journal:  Chem Biol Interact       Date:  2010-12-24       Impact factor: 5.192

Review 2.  Comparative anatomy of the aldo-keto reductase superfamily.

Authors:  J M Jez; M J Bennett; B P Schlegel; M Lewis; T M Penning
Journal:  Biochem J       Date:  1997-09-15       Impact factor: 3.857

Review 3.  Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes.

Authors:  Trevor M Penning; Phumvadee Wangtrakuldee; Richard J Auchus
Journal:  Endocr Rev       Date:  2019-04-01       Impact factor: 19.871

4.  Cloning of the aldehyde reductase gene from a red yeast, Sporobolomyces salmonicolor, and characterization of the gene and its product.

Authors:  K Kita; K Matsuzaki; T Hashimoto; H Yanase; N Kato; M C Chung; M Kataoka; S Shimizu
Journal:  Appl Environ Microbiol       Date:  1996-07       Impact factor: 4.792

5.  Bacterial morphine dehydrogenase further defines a distinct superfamily of oxidoreductases with diverse functional activities.

Authors:  N C Bruce; D L Willey; A F Coulson; J Jeffery
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

6.  Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues.

Authors:  V P Kelly; L S Ireland; E M Ellis; J D Hayes
Journal:  Biochem J       Date:  2000-06-01       Impact factor: 3.857

7.  Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis.

Authors:  Luigi Di Costanzo; Jason E Drury; Trevor M Penning; David W Christianson
Journal:  J Biol Chem       Date:  2008-04-11       Impact factor: 5.157

8.  Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1).

Authors:  Luigi Di Costanzo; Jason E Drury; David W Christianson; Trevor M Penning
Journal:  Mol Cell Endocrinol       Date:  2008-09-19       Impact factor: 4.102

Review 9.  5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1).

Authors:  Mo Chen; Trevor M Penning
Journal:  Steroids       Date:  2014-02-08       Impact factor: 2.668

10.  AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

Authors:  Nikolaos Nikolaou; Laura L Gathercole; Lucy Kirkwood; James E Dunford; Beverly A Hughes; Lorna C Gilligan; Udo Oppermann; Trevor M Penning; Wiebke Arlt; Leanne Hodson; Jeremy W Tomlinson
Journal:  J Steroid Biochem Mol Biol       Date:  2019-02-12       Impact factor: 4.292
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