Literature DB >> 1710574

Pre- and postnatal lead exposure affects the serotonergic system in the immature rat brain.

H R Widmer1, E E Bütikofer, M Schlumpf, W Lichtensteiger.   

Abstract

The effect of pre- and postnatal lead exposure on the development of the serotonergic system in striatum and brain stem was investigated. Serotonin and its metabolite 5-HIAA where determined by HPLC-EC. A significant decrease of 5-HT was detected in the brain stem at postnatal day 28. At both days 6 and 28 postnatal, 5-HIAA was reduced in striatum and brain stem. The results provide support to the hypothesis that developing 5-HT neurons are sensitive to relatively low levels of lead exposure.

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Year:  1991        PMID： 1710574     DOI： 10.1007/bf01959945

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

Review 1.  Prenatal adverse effects of nicotine on the developing brain.

Authors:  W Lichtensteiger; U Ribary; M Schlumpf; B Odermatt; H R Widmer
Journal:  Prog Brain Res       Date:  1988       Impact factor: 2.453

Review 2.  Neuronal unit activity patterns in behaving animals: brainstem and limbic system.

Authors:  D McGinty; R Szymusiak
Journal:  Annu Rev Psychol       Date:  1988       Impact factor: 24.137

3.  The effect of perinatal lead administration on the ontogeny of striatal enkephalin levels in the rat.

Authors:  C Winder; I Kitchen; L B Clayton; S M Gardiner; J M Wilson; P D Lewis
Journal:  Toxicol Appl Pharmacol       Date:  1984-03-30       Impact factor: 4.219

4.  An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields.

Authors:  H G Lidov; M E Molliver
Journal:  Brain Res Bull       Date:  1982-04       Impact factor: 4.077

5.  Neonatal lead exposure in rats: I. Effects on activity and brain metals.

Authors:  M McCarren; C U Eccles
Journal:  Neurobehav Toxicol Teratol       Date:  1983 Sep-Oct

6.  National estimates of blood lead levels: United States, 1976-1980: association with selected demographic and socioeconomic factors.

Authors:  K R Mahaffey; J L Annest; J Roberts; R S Murphy
Journal:  N Engl J Med       Date:  1982-09-02       Impact factor: 91.245

7.  Altered central monoamine response to D-amphetamine in rats chronically exposed to inorganic lead.

Authors:  S M Lasley; R D Greenland; D J Minnema; I A Michaelson
Journal:  Neurochem Res       Date:  1985-07       Impact factor: 3.996

8.  The effect of chronic low level lead exposure on blood-brain barrier function in the developing rat.

Authors:  S R Moorhouse; S Carden; P N Drewitt; B P Eley; R J Hargreaves; D Pelling
Journal:  Biochem Pharmacol       Date:  1988-12-01       Impact factor: 5.858

9.  Pre- and postnatal ontogeny and characterization of dopaminergic D2, serotonergic S2, and spirodecanone binding sites in rat forebrain.

Authors:  A Bruinink; W Lichtensteiger; M Schlumpf
Journal:  J Neurochem       Date:  1983-05       Impact factor: 5.372

10.  Development of the serotonergic system in the rat embryo: an immunocytochemical study.

Authors:  J A Wallace; J M Lauder
Journal:  Brain Res Bull       Date:  1983-04       Impact factor: 4.077
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  1 in total

1.  Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models.

Authors:  Umer Javed Butt; Syed Adnan Ali Shah; Touqeer Ahmed; Saadia Zahid
Journal:  Toxicol Res (Camb)       Date:  2017-10-05       Impact factor: 3.524
  1 in total

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