Literature DB >> 1710305

Correlation of the percentage of activated, CD3 + DR + lymphocytes to serum neopterin level in HIV-seropositive haemophiliacs.

K Pálóczi1, E Ujhelyi, D Fuchs, R Mihalik, D Bánhegyi, S Berkessy, V Salavecz, H Wachter, S R Hollán, G Füst.   

Abstract

The percentage of activated, CD3+ DR+ and CD8+ Leu7+ lymphocytes and the serum neopterin concentration were determined in 17 HIV-seropositive and 10 HIV-seronegative haemophiliacs and in 11 healthy control subjects. All three parameters tested were found to be significantly higher in the seropositive patients than in the seronegative controls. In the seropositive group, a significant positive correlation was found between the neopterin levels and the percentage of CD3+ DR+ cells. By contrast, no significant negative or positive correlation was observed between the neopterin levels and the percentage of the CD8+ Leu7+ subset. These data suggest that in the HIV-infected patients the activated T cells responsible for the stimulation of macrophages to produce neopterin are those that do not carry CD8.

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Year:  1991        PMID： 1710305     DOI： 10.1007/bf01665853

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  10 in total

1.  Urinary neopterin concentrations and T-cell subset data in HIV-1 infection.

Authors:  G Reibnegger; D Fuchs; J J Goedert; A Hausen; A Krämer; E R Werner; G Werner-Felmayer; M P Dierich; H Wachter
Journal:  Klin Wochenschr       Date:  1990-01-04

2.  Lymphocyte activation by HIV-1 envelope glycoprotein.

Authors:  H Kornfeld; W W Cruikshank; S W Pyle; J S Berman; D M Center
Journal:  Nature       Date:  1988-09-29       Impact factor: 49.962

Review 3.  Natural history of HIV infection.

Authors:  A R Moss; P Bacchetti
Journal:  AIDS       Date:  1989-02       Impact factor: 4.177

4.  Serum neopterin levels as predictor of AIDS.

Authors:  J R Bogner; A Matuschke; B Heinrich; E Eberle; F D Goebel
Journal:  Klin Wochenschr       Date:  1988-10-17

5.  Amplification of HTLV-III/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic responses.

Authors:  J B Margolick; D J Volkman; T M Folks; A S Fauci
Journal:  J Immunol       Date:  1987-03-15       Impact factor: 5.422

Review 6.  AIDS as immune system activation. II. The panergic imnesia hypothesis.

Authors:  M S Ascher; H W Sheppard
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1990

7.  Neopterin: a predictive marker of acquired immune deficiency syndrome in human immunodeficiency virus infection.

Authors:  A Krämer; S Z Wiktor; D Fuchs; S Milstien; M H Gail; F J Yellin; R J Biggar; H Wachter; S Kaufman; W A Blattner
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1989

8.  Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.

Authors:  D Fuchs; A Hausen; G Reibnegger; E R Werner; G Werner-Felmayer; M P Dierich; H Wachter
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1989

9.  Expansion of activated T lymphocytes (CD3 + HLA/DR +) detectable in early stages of HIV-1 infection.

Authors:  J R Bogner; A Matuschke; B Heinrich; M A Schreiber; C Nerl; F D Goebel
Journal:  Klin Wochenschr       Date:  1990-04-17

10.  Interrelationships between serologic markers of immune activation and T lymphocyte subsets in HIV infection.

Authors:  H E Prince; S Kleinman; C Czaplicki; J John; A E Williams
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1990
  10 in total
  1 in total

Review 1.  Neopterin as a biomarker of immune response in cancer patients.

Authors:  Bohuslav Melichar; Martina Spisarová; Marie Bartoušková; Lenka Kujovská Krčmová; Lenka Javorská; Hana Študentová
Journal:  Ann Transl Med       Date:  2017-07
  1 in total

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