AIM: The purpose of the present study was to test the hypothesis that chronic inflammation impairs vascular function and leads to an arterial pulse wave velocity (PWV) increase in patients with familial Mediterranean fever (FMF). PATIENTS AND METHODS: Twenty-three patients (17 women) with FMF, and 23 age- and sex-matched controls were recruited. Aortic PWV was determined by using an automatic device (Complior Colson, Createch Industrie, France) that allowed on-line pulse wave recording and automatic calculation of the PWV. RESULTS: The PWV was slightly higher in patients with FMF than in control subjects (P=0.05). A significant correlation between PWV and age (P<0.001, r=0.67), body mass index (P<0.001, r=0.52) and leukocytes (P<0.001, r=0.66) was found in both groups combined and also in patients with FMF (P<0.001, r=0.73; P=0.01, r=0.52; P<0.001, r=0.69, respectively). CONCLUSION: The PWV was slightly higher in patients with FMF compared with control subjects. Colchicine, an anti-inflammatory drug treatment, may have reduced the expected increased level of PWV in FMF patients. PWV is influenced by age, body mass index and leukocytes.
AIM: The purpose of the present study was to test the hypothesis that chronic inflammation impairs vascular function and leads to an arterial pulse wave velocity (PWV) increase in patients with familial Mediterranean fever (FMF). PATIENTS AND METHODS: Twenty-three patients (17 women) with FMF, and 23 age- and sex-matched controls were recruited. Aortic PWV was determined by using an automatic device (Complior Colson, Createch Industrie, France) that allowed on-line pulse wave recording and automatic calculation of the PWV. RESULTS: The PWV was slightly higher in patients with FMF than in control subjects (P=0.05). A significant correlation between PWV and age (P<0.001, r=0.67), body mass index (P<0.001, r=0.52) and leukocytes (P<0.001, r=0.66) was found in both groups combined and also in patients with FMF (P<0.001, r=0.73; P=0.01, r=0.52; P<0.001, r=0.69, respectively). CONCLUSION: The PWV was slightly higher in patients with FMF compared with control subjects. Colchicine, an anti-inflammatory drug treatment, may have reduced the expected increased level of PWV in FMFpatients. PWV is influenced by age, body mass index and leukocytes.
Authors: Melinda Wong; Ling Toh; Andrew Wilson; Kevin Rowley; Connie Karschimkus; David Prior; Evange Romas; Laurence Clemens; George Dragicevic; Harry Harianto; Ian Wicks; Geoff McColl; James Best; Alicia Jenkins Journal: Arthritis Rheum Date: 2003-01
Authors: Yusuf Tavil; Kemal Ureten; Mehmet Akif Oztürk; Nihat Sen; Mehmet Güngör Kaya; Mustafa Cemri; Atiye Cengel Journal: Clin Rheumatol Date: 2007-07-24 Impact factor: 2.980