OBJECTIVE: To determine whether memory loss in patients with multiple sclerosis (MS) results from faulty encoding or retrieval, we correlated extent of T2-weighted lesion involvement with brain activation patterns on fMRI scans obtained while patients performed a verbal episodic memory task. METHODS: We performed a neurologic examination, neuropsychological testing, and an event-related fMRI scan on 36 patients with relapsing-remitting MS. In addition, we obtained T2-weighted structural MRI scans to measure lesion volume. We performed a regression analysis to examine the association between lesion volume and regional brain activation. RESULTS: Increasing lesion volume correlated with increasing magnitude of brain activation, primarily in the left frontal and parietal association cortices. Significant correlations of function with lesion volume were primarily observed during the memory retrieval phase of the task. CONCLUSIONS: These results extend previous fMRI studies in multiple sclerosis (MS) by demonstrating an association between greater disease burden and increased neural recruitment during episodic memory. In addition, the stronger correlations observed between lesion volume and brain activation during retrieval than encoding would suggest that retrieval processes are more affected by MS-related cerebral pathology.
OBJECTIVE: To determine whether memory loss in patients with multiple sclerosis (MS) results from faulty encoding or retrieval, we correlated extent of T2-weighted lesion involvement with brain activation patterns on fMRI scans obtained while patients performed a verbal episodic memory task. METHODS: We performed a neurologic examination, neuropsychological testing, and an event-related fMRI scan on 36 patients with relapsing-remitting MS. In addition, we obtained T2-weighted structural MRI scans to measure lesion volume. We performed a regression analysis to examine the association between lesion volume and regional brain activation. RESULTS: Increasing lesion volume correlated with increasing magnitude of brain activation, primarily in the left frontal and parietal association cortices. Significant correlations of function with lesion volume were primarily observed during the memory retrieval phase of the task. CONCLUSIONS: These results extend previous fMRI studies in multiple sclerosis (MS) by demonstrating an association between greater disease burden and increased neural recruitment during episodic memory. In addition, the stronger correlations observed between lesion volume and brain activation during retrieval than encoding would suggest that retrieval processes are more affected by MS-related cerebral pathology.
Authors: Meggan Mackay; Mathew P Bussa; Cynthia Aranow; Aziz M Uluğ; Bruce T Volpe; Patricio T Huerta; Miklos Argyelan; Arthur Mandel; Joy Hirsch; Betty Diamond; David Eidelberg Journal: Mol Med Date: 2011-09-21 Impact factor: 6.354
Authors: Megan Walsh; Caroline A Montojo; Yi-Shin Sheu; Steven A Marchette; Daniel M Harrison; Scott D Newsome; Feng Zhou; Amy L Shelton; Susan M Courtney Journal: Brain Connect Date: 2011
Authors: Katherine A Koenig; Stephen M Rao; Mark J Lowe; Jian Lin; Ken E Sakaie; Lael Stone; Robert A Bermel; Bruce D Trapp; Micheal D Phillips Journal: Mult Scler Date: 2018-03-07 Impact factor: 6.312
Authors: M Filippi; M A Rocca; R H B Benedict; J DeLuca; J J G Geurts; S A R B Rombouts; M Ron; G Comi Journal: Neurology Date: 2010-12-07 Impact factor: 9.910
Authors: Hanneke E Hulst; Menno M Schoonheim; Stefan D Roosendaal; Veronica Popescu; Lizanne J S Schweren; Ysbrand D van der Werf; Leo H Visser; Chris H Polman; Frederik Barkhof; Jeroen J G Geurts Journal: Hum Brain Mapp Date: 2011-09-06 Impact factor: 5.038