Brent Tipping1, Linda de Villiers, Sally Candy, Helen Wainwright. 1. Stroke Unit, Division of Geriatrics, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, South Africa. btipping@mweb.co.za
Abstract
BACKGROUND: Intracranial aneurysms related to human immunodeficiency virus (HIV) infection have been well described in pediatric patients but not in adults. OBJECTIVE: To describe a case of intracranial large-vessel aneurysmal vasculopathy causing stroke in a 27-year-old HIV-infected woman. DESIGN: Comparison of clinical and histological data with previously published cases. SETTING: A referral hospital stroke unit. Patient A 27-year-old HIV-infected woman presenting with stroke; neuroimaging demonstrated fusiform aneurysmal dilation of the left internal carotid and the left middle cerebral artery and its branches. RESULTS: Autopsy showed degeneration of the elastic lamina, myxoid degeneration, and medial atrophy, causing consequent ectasia of the involved intracranial vessels. CONCLUSION: Aneurysmal dilation of the intracranial arteries occurs in HIV-infected adults, but the pathogenic role of HIV remains unknown.
BACKGROUND:Intracranial aneurysms related to human immunodeficiency virus (HIV) infection have been well described in pediatric patients but not in adults. OBJECTIVE: To describe a case of intracranial large-vessel aneurysmal vasculopathy causing stroke in a 27-year-old HIV-infectedwoman. DESIGN: Comparison of clinical and histological data with previously published cases. SETTING: A referral hospital stroke unit. Patient A 27-year-old HIV-infectedwoman presenting with stroke; neuroimaging demonstrated fusiform aneurysmal dilation of the left internal carotid and the left middle cerebral artery and its branches. RESULTS: Autopsy showed degeneration of the elastic lamina, myxoid degeneration, and medial atrophy, causing consequent ectasia of the involved intracranial vessels. CONCLUSION:Aneurysmal dilation of the intracranial arteries occurs in HIV-infected adults, but the pathogenic role of HIV remains unknown.
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