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Literature DB >> 17101672

In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.

Barbara D Foleno¹, Darren Abbanat, Raul M Goldschmidt, Robert K Flamm, Steve D Paget, Glenda C Webb, Ellyn Wira, Mark J Macielag, Karen Bush.

Abstract

RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of < or =4 microg/ml, generally exhibiting two- to fourfold-greater potency than that of linezolid. Time-kill studies demonstrated bacteriostatic effects for both RWJ-416457 and linezolid.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 17101672 PMCID： PMC1797661 DOI： 10.1128/AAC.01017-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

Review 1. Antibacterial drug discovery in the 21st century.

Authors: K Bush
Journal: Clin Microbiol Infect Date: 2004-11 Impact factor: 8.067

Review 2. Update on linezolid: the first oxazolidinone antibiotic.

Authors: Mark H Wilcox
Journal: Expert Opin Pharmacother Date: 2005-10 Impact factor: 3.889

Review 3. The emergence of infections with community-associated methicillin resistant Staphylococcus aureus.

Authors: B M W Diederen; J A J W Kluytmans
Journal: J Infect Date: 2005-11-09 Impact factor: 6.072

4. Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions.

Authors: D L Shinabarger; K R Marotti; R W Murray; A H Lin; E P Melchior; S M Swaney; D S Dunyak; W F Demyan; J M Buysse
Journal: Antimicrob Agents Chemother Date: 1997-10 Impact factor: 5.191

Review 5. Linezolid in vitro: mechanism and antibacterial spectrum.

Authors: David M Livermore
Journal: J Antimicrob Chemother Date: 2003-05 Impact factor: 5.790

6. In vitro susceptibilities of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum to sparfloxacin and PD 127391.

Authors: K B Waites; L B Duffy; T Schmid; D Crabb; M S Pate; G H Cassell
Journal: Antimicrob Agents Chemother Date: 1991-06 Impact factor: 5.191

Review 7. Antimicrobial resistance among gram-positive organisms in the intensive care unit.

Authors: Nina M Clark; Ellie Hershberger; Marcus J Zervosc; Joseph P Lynch
Journal: Curr Opin Crit Care Date: 2003-10 Impact factor: 3.687

Review 8. Oxazolidinone structure-activity relationships leading to linezolid.

Authors: Michael R Barbachyn; Charles W Ford
Journal: Angew Chem Int Ed Engl Date: 2003-05-09 Impact factor: 15.336

9. Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.

Authors: Jerry R Colca; William G McDonald; Daniel J Waldon; Lisa M Thomasco; Robert C Gadwood; Eric T Lund; Gregory S Cavey; W Rodney Mathews; Lonnie D Adams; Eric T Cecil; James D Pearson; Jeffrey H Bock; John E Mott; Dean L Shinabarger; Liqun Xiong; Alexander S Mankin
Journal: J Biol Chem Date: 2003-04-10 Impact factor: 5.157

Review 10. Hidden epidemic of macrolide-resistant pneumococci.

Authors: Keith P Klugman; John R Lonks
Journal: Emerg Infect Dis Date: 2005-06 Impact factor: 6.883

7 in total

1. In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci.

Authors: David M Livermore; Marina Warner; Shazad Mushtaq; Sarah North; Neil Woodford
Journal: Antimicrob Agents Chemother Date: 2007-01-08 Impact factor: 5.191

Review 2. Newer antibacterial drugs for a new century.

Authors: Gina Devasahayam; William M Scheld; Paul S Hoffman
Journal: Expert Opin Investig Drugs Date: 2010-02 Impact factor: 6.206

3. Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus.

Authors: Stephan Schmidt; Sreedharan Nair Sabarinath; April Barbour; Darren Abbanat; Prasarn Manitpisitkul; Sue Sha; Hartmut Derendorf
Journal: Antimicrob Agents Chemother Date: 2009-09-28 Impact factor: 5.191