| Literature DB >> 1710144 |
N D Heindel1, H R Zhao, J Leiby, J M VanDongen, C J Lacey, D A Lima, B Shabsoug, J H Buzby.
Abstract
The coupling of ellipticine and CI-921, two antineoplastic pharmaceuticals, to polyaldehyde dextran can be carried out under mild reaction conditions with novel acid hydrazides of the parent drugs. The resulting acyl hydrazones resist hydrolytic and enzymatic cleavage and offer a method for drug loading via dextran conjugates to monoclonal antibodies.Entities:
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Year: 1990 PMID： 1710144 DOI： 10.1021/bc00001a010
Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774