The early impact of feeding on infant breathing-swallowing coordination.

This longitudinal study assessed the coordination of nutritive and non-nutritive swallowing with breathing in 10 healthy term infants from birth to 1 year of age. Swallows were classified into five respiratory-phase categories: mid-inspiration (II), mid-expiration (EE), inspiratory-expiratory cusp (IE), expiratory-inspiratory cusp (EI), and mid-pause (P). Breathing-swallowing coordination differed markedly between the two swallowing conditions, especially between 2 weeks and 2 months. Significant condition effects were found in up to four respiratory-phase categories (II, IE, EI, and P). The condition effect was minimal from 9 months with only IE swallow proportions differing between conditions. These data suggest a 'critical period' in infantile neural response to oropharyngeal stimulation during feeding and that the impact of this on infants with neurological and/or respiratory disorders should be further investigated.