BACKGROUND: Despite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment. OBJECTIVE: The aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control. METHODS: We evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01+/-1.6 years old; body mass index 36.54+/-2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed. RESULTS: The results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05+/-1.55 to 3.37+/-1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents. CONCLUSIONS: The short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.
BACKGROUND: Despite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment. OBJECTIVE: The aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control. METHODS: We evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obeseparticipants (17.01+/-1.6 years old; body mass index 36.54+/-2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed. RESULTS: The results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05+/-1.55 to 3.37+/-1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents. CONCLUSIONS: The short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.
Authors: B G P Koot; O H van der Baan-Slootweg; S Vinke; A E Bohte; C L J Tamminga-Smeulders; P L M Jansen; J Stoker; M A Benninga Journal: Int J Obes (Lond) Date: 2015-08-28 Impact factor: 5.095
Authors: Miriam B Vos; Stephanie H Abrams; Sarah E Barlow; Sonia Caprio; Stephen R Daniels; Rohit Kohli; Marialena Mouzaki; Pushpa Sathya; Jeffrey B Schwimmer; Shikha S Sundaram; Stavra A Xanthakos Journal: J Pediatr Gastroenterol Nutr Date: 2017-02 Impact factor: 2.839
Authors: Lian Tock; Ana R Dâmaso; Aline de Piano; June Carnier; Priscila L Sanches; Henrique Manoel Lederman; Regina M Y Ernandes; Marco Túlio de Mello; Sérgio Tufik Journal: J Obes Date: 2010-02-09
Authors: Antonio E Aquino; Marcela Sene-Fiorese; Fernanda R Paolillo; Fernanda O Duarte; Jorge C Oishi; Airton A Pena; Ana C G O Duarte; Michael R Hamblin; Vanderlei S Bagnato; Nivaldo A Parizotto Journal: Lasers Med Sci Date: 2012-11-14 Impact factor: 3.161