Frances E Jensen1. 1. Department of Neurology, Children's Hospital, Program in Neurobiology, Harvard Medical School, Boston, MA 02114, USA. frances.jensen@childrens.harvard.edu
Abstract
PURPOSE OF REVIEW: To review the unique pattern of developmentally regulated factors that govern the susceptibility of the brain during the preterm and term windows of development. RECENT FINDINGS: The neonatal brain shows unique regional differences in susceptibility to injury. In response to the common insult of hypoxia/ischemia, the preterm brain exhibits regional white matter susceptibility, while gray matter is affected in the term brain. Developmental regulation of specific cellular factors is likely to underlie these age-specific differences. SUMMARY: A better understanding of these factors could contribute to the development of new age-specific therapeutic strategies with clinical potential for disorders such as periventricular leukomalacia in the preterm and neonatal seizures in the term infant.
PURPOSE OF REVIEW: To review the unique pattern of developmentally regulated factors that govern the susceptibility of the brain during the preterm and term windows of development. RECENT FINDINGS: The neonatal brain shows unique regional differences in susceptibility to injury. In response to the common insult of hypoxia/ischemia, the preterm brain exhibits regional white matter susceptibility, while gray matter is affected in the term brain. Developmental regulation of specific cellular factors is likely to underlie these age-specific differences. SUMMARY: A better understanding of these factors could contribute to the development of new age-specific therapeutic strategies with clinical potential for disorders such as periventricular leukomalacia in the preterm and neonatal seizures in the term infant.
Authors: Sarah E Andiman; Robin L Haynes; Felicia L Trachtenberg; Saraid S Billiards; Rebecca D Folkerth; Joseph J Volpe; Hannah C Kinney Journal: Brain Pathol Date: 2010-02-08 Impact factor: 6.508
Authors: Yuma A Bijleveld; Timo R de Haan; Johanna H van der Lee; Floris Groenendaal; Peter H Dijk; Arno van Heijst; Rogier C J de Jonge; Koen P Dijkman; Henrica L M van Straaten; Monique Rijken; Inge A Zonnenberg; Filip Cools; Alexandra Zecic; Debbie H G M Nuytemans; Anton H van Kaam; Ron A A Mathôt Journal: Antimicrob Agents Chemother Date: 2018-03-27 Impact factor: 5.191