Literature DB >> 1709914

DNA sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: identification of polymorphic alleles.

K H You1, C L Hsieh, C Hayes, N Stahl, U Francke, B Popko.   

Abstract

We have cloned and characterized the mouse gene, P0, that encodes the predominant protein of peripheral myelin. Similar to the rat gene, the mouse P0 gene is encoded by six exons that span about 7 kb of DNA. The DNA sequence of the mouse gene is highly homologous with the rat gene, including the regions believed to be important in transcriptional control. Furthermore, the P0 protein appears well conserved throughout evolution. The gene was mapped to mouse chromosome 1 by Southern analysis of a Chinese hamster x mouse somatic cell hybrid panel. Several polymorphic restriction enzyme sites were identified within the P0 locus. Recombinant inbred strain mapping has linked the P0 gene to Ly-9/Ly/Sap in a region corresponding to band 1H3.

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Year:  1991        PMID： 1709914     DOI： 10.1016/0888-7543(91)90370-t

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  12 in total

1.  The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice.

Authors:  Michele A Kelly; Malcolm J Low; Tamara J Phillips; Edward K Wakeland; Masashi Yanagisawa
Journal:  Mamm Genome       Date:  2003-10       Impact factor: 2.957

Review 2.  Mouse chromosome 1.

Authors:  M F Seldin
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 3.  Mouse chromosome 1.

Authors:  M F Seldin; T H Roderick; B Paigen
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

4.  Four novel mutations of the myelin protein zero gene presenting as a mild and late-onset polyneuropathy.

Authors:  Ilka Kleffner; Anja Schirmacher; Burkhard Gess; Matthias Boentert; Peter Young
Journal:  J Neurol       Date:  2010-06-18       Impact factor: 4.849

5.  Phylogenetically conserved amino acids of MBP and P0 from amphibian myelin.

Authors:  J Karthigasan; T K Bauer; D B Teplow; R A Saavedra; D A Kirschner
Journal:  J Mol Neurosci       Date:  1992       Impact factor: 3.444

6.  Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients.

Authors:  Y Su; D G Brooks; L Li; J Lepercq; J A Trofatter; J V Ravetch; R V Lebo
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

7.  Induced reciprocal translocation in transgenic mice near sites of transgene integration.

Authors:  U Francke; C L Hsieh; D Kelly; E Lai; B Popko
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

8.  Peripheral myelin of Xenopus laevis: role of electrostatic and hydrophobic interactions in membrane compaction.

Authors:  XiaoYang Luo; Jana Cerullo; Tamara Dawli; Christina Priest; Zaid Haddadin; Angela Kim; Hideyo Inouye; Brian P Suffoletto; Robin L Avila; Jonathan P B Lees; Deepak Sharma; Bo Xie; Catherine E Costello; Daniel A Kirschner
Journal:  J Struct Biol       Date:  2007-11-01       Impact factor: 2.867

9.  Pathogenesis of axonal dystrophy and demyelination in alphaA-crystallin-expressing transgenic mice.

Authors:  A F Van Rijk; M A M Sweers; G F M Merkx; M Lammens; H Bloemendal
Journal:  Int J Exp Pathol       Date:  2003-04       Impact factor: 1.925

10.  Rapid screening of myelin genes in CMT1 patients by SSCP analysis: identification of new mutations and polymorphisms in the P0 gene.

Authors:  E Nelis; V Timmerman; P De Jonghe; A Vandenberghe; D Pham-Dinh; A Dautigny; J J Martin; C Van Broeckhoven
Journal:  Hum Genet       Date:  1994-12       Impact factor: 4.132
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