| Literature DB >> 17099084 |
S G Santhana Krishnan1, S G S Krishnan, R Pathalapati, L Kaplan, R K Cobbs.
Abstract
The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported. Laboratory evaluation showed high levels of thyroid-stimulating hormone (TSH). The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism. TSH remained persistently raised and the patient became thyrotoxic. Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances. TSH levels were normalised with the addition of mouse serum to the patient's sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.Entities:
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Year: 2006 PMID： 17099084 PMCID： PMC2660509 DOI： 10.1136/pmj.2006.049809
Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401