BACKGROUND: The responsiveness of the endurance shuttle walk to functional changes following bronchodilation has recently been reported. The current literature suggests that the 6 min walking test (6MWT) is less responsive to bronchodilation than the endurance shuttle walk. AIM: To compare bronchodilator-induced changes in exercise performance with the 6MWT and the endurance shuttle walk. METHODS: In a randomised, double-blind, placebo-controlled, crossover trial, 14 patients with chronic obstructive pulmonary disease (forced expiratory volume in 1 s (FEV(1)) 50 (8)% predicted) completed two 6MWTs and two endurance shuttle walks, each preceded by nebulised placebo or 500 microg ipratropium bromide. Cardiorespiratory parameters were monitored during each walking test with a portable telemetric gas analyser. Quadriceps twitch force was measured by magnetic stimulation of the femoral nerve before and after each walking test. RESULTS: The 6 min walking distance did not change significantly after bronchodilation despite a significant increase in FEV(1) of 0.18 (0.09) litres (p<0.001). A similar change in FEV(1) (0.18 (0.12) litres, p<0.001) was associated with a significant improvement in the distance walked on the endurance shuttle walk (Deltadistance ipratropium bromide--placebo = 144 (219) m, p = 0.03). Quadriceps muscle fatigue was infrequent (<15% of patients) after both walking tests. CONCLUSION: The endurance shuttle walk is more responsive than the 6MWT for detecting changes in exercise performance following bronchodilation.
RCT Entities:
BACKGROUND: The responsiveness of the endurance shuttle walk to functional changes following bronchodilation has recently been reported. The current literature suggests that the 6 min walking test (6MWT) is less responsive to bronchodilation than the endurance shuttle walk. AIM: To compare bronchodilator-induced changes in exercise performance with the 6MWT and the endurance shuttle walk. METHODS: In a randomised, double-blind, placebo-controlled, crossover trial, 14 patients with chronic obstructive pulmonary disease (forced expiratory volume in 1 s (FEV(1)) 50 (8)% predicted) completed two 6MWTs and two endurance shuttle walks, each preceded by nebulised placebo or 500 microg ipratropium bromide. Cardiorespiratory parameters were monitored during each walking test with a portable telemetric gas analyser. Quadriceps twitch force was measured by magnetic stimulation of the femoral nerve before and after each walking test. RESULTS: The 6 min walking distance did not change significantly after bronchodilation despite a significant increase in FEV(1) of 0.18 (0.09) litres (p<0.001). A similar change in FEV(1) (0.18 (0.12) litres, p<0.001) was associated with a significant improvement in the distance walked on the endurance shuttle walk (Deltadistance ipratropium bromide--placebo = 144 (219) m, p = 0.03). Quadriceps muscle fatigue was infrequent (<15% of patients) after both walking tests. CONCLUSION: The endurance shuttle walk is more responsive than the 6MWT for detecting changes in exercise performance following bronchodilation.
Authors: D A Mahler; J F Donohue; R A Barbee; M D Goldman; N J Gross; M E Wisniewski; S W Yancey; B A Zakes; K A Rickard; W H Anderson Journal: Chest Date: 1999-04 Impact factor: 9.410
Authors: A Grove; B J Lipworth; P Reid; R P Smith; L Ramage; C G Ingram; R J Jenkins; J H Winter; D P Dhillon Journal: Thorax Date: 1996-07 Impact factor: 9.139
Authors: Wytske A Altenburg; Marieke L Duiverman; Nick H T Ten Hacken; Huib A M Kerstjens; Mathieu H G de Greef; Peter J Wijkstra; Johan B Wempe Journal: Respir Res Date: 2015-02-19