| Literature DB >> 17098477 |
Sujoy Khan1, Michael D Tarzi, Philip C Doré, W A C Sewell, Hilary J Longhurst.
Abstract
The association of systemic lupus erythematosus and hereditary angioedema (HAE) has formed the basis of numerous case reports and is hypothesised to result from consumption of complement C4 with consequent impaired clearance of apoptotic cells. We describe the development of frank lupus or lupus-like syndrome in four HAE patients with uncontrolled angioedema and low levels of serum C4. Measures that limit hypocomplementaemia in HAE may reduce the incidence of secondary SLE.Entities:
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Year: 2006 PMID： 17098477 DOI： 10.1016/j.clim.2006.09.015
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969