| Literature DB >> 17098428 |
Ashok V Purandare1, Honghe Wan, John E Somerville, Christine Burke, Wayne Vaccaro, XiaoXia Yang, Kim W McIntyre, Michael A Poss.
Abstract
The design, synthesis, and SAR studies of 'core' variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was efficacious in a murine allergic inflammation model (ED50 approximately 10 mg/kg).Entities:
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Year: 2006 PMID： 17098428 DOI： 10.1016/j.bmcl.2006.10.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823