| Literature DB >> 17097774 |
Thomas Höhler1, Gudrun Groeger-Bicanic, Bernard Hoet, Michel Stoffel.
Abstract
Response to hepatitis A and B vaccines has been reported to decline with age. This open, prospective, single-site study examined the long-term response to the combined hepatitis A/B vaccine Twinrix in 98 primary responders aged 45-67 years. Levels of antibody against hepatitis A virus (HAV) and hepatitis B surface antigen (HBs) were tested 30 months after initial vaccination. At this stage, all participants remained seropositive for anti-HAV and 70% for anti-HBs. A booster vaccination was offered to those who had responded to the first vaccination but then lost protective levels of anti-HBs. An anamnestic response was observed in all cases.Entities:
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Year: 2006 PMID： 17097774 DOI： 10.1016/j.vaccine.2006.10.024
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641