| Literature DB >> 17097771 |
Sunil K Singh1, S Shivaramakrishna, V Saibaba, K Srinivas Rao, K Ravi Ganesh, R Vasudev, P Praveen Kumar, J Moses Babu, K Vyas, Y Koteswar Rao, J Iqbal.
Abstract
ortho-Acylation attempt of benzenesulfonamide afforded the corresponding hemiaminal as major product. The in situ reduction of the reaction mixture, reported herein, directly provided 2-hydroxyalkyl benzenesulfonamide, an important pharmacophoric element for designing drug-like scaffolds. Its application is demonstrated through designing a novel series of 1,5-diarylpyrazoles for cyclooxygenase-2 (COX-2) inhibition.Entities:
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Year: 2006 PMID： 17097771 DOI： 10.1016/j.ejmech.2006.09.021
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514