Literature DB >> 17097758

Challenges and obstacles of ocular pharmacokinetics and drug delivery.

Arto Urtti1.   

Abstract

Modern biological research has produced increasing number of promising therapeutic possibilities for medical treatment. These include for example growth factors, monoclonal antibodies, gene knockdown methods, gene therapy, surgical transplantations and tissue engineering. Ocular application of these possibilities involves drug delivery in many forms. Ocular drug delivery is hampered by the barriers protecting the eye. This review presents an overview of the essential factors in ocular pharmacokinetics and selected pharmacological future challenges in ophthalmology.

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Year:  2006        PMID： 17097758     DOI： 10.1016/j.addr.2006.07.027

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  161 in total

1.  Ocular pharmacokinetic study of a corticosteroid by 19F MR.

Authors:  Xin Liu; S Kevin Li; Eun-Kee Jeong
Journal:  Exp Eye Res       Date:  2010-06-09       Impact factor: 3.467

Review 2.  Ocular drug delivery.

Authors:  Ripal Gaudana; Hari Krishna Ananthula; Ashwin Parenky; Ashim K Mitra
Journal:  AAPS J       Date:  2010-05-01       Impact factor: 4.009

3.  Prediction of the corneal permeability of drug-like compounds.

Authors:  Heidi Kidron; Kati-Sisko Vellonen; Eva M del Amo; Anita Tissari; Arto Urtti
Journal:  Pharm Res       Date:  2010-04-13       Impact factor: 4.200

4.  Cytoprotective effect of hyaluronic acid and hydroxypropyl methylcellulose against DNA damage induced by thimerosal in Chang conjunctival cells.

Authors:  Juan Ye; Huina Zhang; Han Wu; Changjun Wang; Xin Shi; Jiajun Xie; Jinjing He; Jun Yang
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2012-06-24       Impact factor: 3.117

5.  Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye.

Authors:  Deb K Mojumder; Francis A Concepcion; Shil K Patel; Andrew J Barkmeier; Petros E Carvounis; John H Wilson; Eric R Holz; Theodore G Wensel
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-05-26       Impact factor: 4.799

Review 6.  Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies.

Authors:  Abhirup Mandal; Rohit Bisht; Ilva D Rupenthal; Ashim K Mitra
Journal:  J Control Release       Date:  2017-01-11       Impact factor: 9.776

7.  In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma.

Authors:  Tamara Martínez; Maria Victoria González; Ingo Roehl; Natalia Wright; Covadonga Pañeda; Ana Isabel Jiménez
Journal:  Mol Ther       Date:  2013-09-12       Impact factor: 11.454

Review 8.  The therapeutic potential of intraocular depot steroid systems: developments aimed at prolonging duration of efficacy.

Authors:  Martin M Nentwich; Michael W Ulbig
Journal:  Dtsch Arztebl Int       Date:  2012-09-14       Impact factor: 5.594

Review 9.  The suprachoroidal space as a route of administration to the posterior segment of the eye.

Authors:  Bryce Chiang; Jae Hwan Jung; Mark R Prausnitz
Journal:  Adv Drug Deliv Rev       Date:  2018-03-12       Impact factor: 15.470

Review 10.  Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

Authors:  Prit Lakhani; Akash Patil; Soumyajit Majumdar
Journal:  J Ocul Pharmacol Ther       Date:  2018-11-08       Impact factor: 2.671
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