| Literature DB >> 17097645 |
Stephane Perrier1, Froogh Darakhshan, Eric Hajduch.
Abstract
Interleukin-1 receptor antagonist (IL-1ra) has been shown to play a crucial role in the prevention of various inflammatory diseases. There is also convincing evidence that IL-1ra is able to counteract inflammatory effects of IL-1 members implicated in insulin resistance and diabetes. However, the use of knock-out animal models provides evidence to the contrary and the role of IL-1ra in obesity-linked anomalies remains controversial. This minireview gets an insight into recent findings on the implication of IL-1ra and its gene polymorphism in diabetes and obesity, discusses the potential dual effects of IL-1ra observed in different models, and comments on future directions.Entities:
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Year: 2006 PMID： 17097645 DOI： 10.1016/j.febslet.2006.10.061
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124