Literature DB >> 17096568

Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues.

Stefania Fioravanti1, Lucio Pellacani, Paolo A Tardella, Alberto Morreale, Giuseppe Del Signore.   

Abstract

A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.

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Year:  2006        PMID: 17096568     DOI: 10.1021/cc060029k

Source DB:  PubMed          Journal:  J Comb Chem        ISSN: 1520-4766


  2 in total

1.  3-(1H-1,3-Benzimidazol-2-yl)-2,7-dimeth-oxy-quinoline.

Authors:  Hayette Alliouche; Sofiane Bouacida; Thierry Roisnel; Ali Belfaitah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-07-18

2.  Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides.

Authors:  Stefania Fioravanti; Davide Massari; Alberto Morreale; Lucio Pellacani; Paolo A Tardella
Journal:  Tetrahedron       Date:  2008-01-31       Impact factor: 2.457

  2 in total

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