BACKGROUND: Little is known on the long-term course of early manganese (Mn) neurotoxic effects. Mn alloy workers were examined in a follow-up study 14 years after exposure ceased at a Canadian facility. METHODS: The same battery of neurofunctional tests used in the initial examination in 1990 was administered to 77 Mn-workers and 81 referents in 2004. RESULTS: Manganese-workers had poorer scores compared to referents both in the initial and follow-up examinations for several motor tasks of the Luria Motor Scale. At follow-up, older Mn-workers (>45 years at cessation of exposure) had poorer scores than referents for tests of cognitive flexibility. Cumulated exposure was associated with poorer test scores for certain neuromotor and cognitive tests and on a mood scale. Differences on certain tests observed at initial examination were not present at follow-up. CONCLUSIONS: Manganese exposure was associated with persistent deficits for certain neuromotor functions, cognitive flexibility, and adVerse mood states, while recovery occurred for other functions. (c) 2007 Wiley-Liss, Inc.
BACKGROUND: Little is known on the long-term course of early manganese (Mn) neurotoxic effects. Mn alloy workers were examined in a follow-up study 14 years after exposure ceased at a Canadian facility. METHODS: The same battery of neurofunctional tests used in the initial examination in 1990 was administered to 77 Mn-workers and 81 referents in 2004. RESULTS:Manganese-workers had poorer scores compared to referents both in the initial and follow-up examinations for several motor tasks of the Luria Motor Scale. At follow-up, older Mn-workers (>45 years at cessation of exposure) had poorer scores than referents for tests of cognitive flexibility. Cumulated exposure was associated with poorer test scores for certain neuromotor and cognitive tests and on a mood scale. Differences on certain tests observed at initial examination were not present at follow-up. CONCLUSIONS:Manganese exposure was associated with persistent deficits for certain neuromotor functions, cognitive flexibility, and adVerse mood states, while recovery occurred for other functions. (c) 2007 Wiley-Liss, Inc.
Authors: Gunilla Wastensson; Gerd Sallsten; Rita Bast-Pettersen; Lars Barregard Journal: Int Arch Occup Environ Health Date: 2011-10-29 Impact factor: 3.015
Authors: Michael Aschner; Keith M Erikson; Elena Herrero Hernández; Elena Herrero Hernández; Ronald Tjalkens Journal: Neuromolecular Med Date: 2009 Impact factor: 3.843
Authors: Jolyn Fernandes; Joshua D Chandler; Ken H Liu; Karan Uppal; Li Hao; Xin Hu; Young-Mi Go; Dean P Jones Journal: Toxicol Sci Date: 2019-05-01 Impact factor: 4.849
Authors: Stephane A Beaudin; Barbara J Strupp; Walter Uribe; Lauren Ysais; Myla Strawderman; Donald R Smith Journal: Neurotoxicol Teratol Date: 2017-03-28 Impact factor: 3.763
Authors: Z García-Chimalpopoca; D Hernández-Bonilla; M Cortez-Lugo; C Escamilla-Núñez; A Schilmann; H Riojas-Rodríguez; S Rodríguez-Dozal; S Montes; L A Tristán-López; M Catalán-Vázquez; C Rios Journal: Neurotox Res Date: 2019-05-30 Impact factor: 3.911
Authors: Dallas M Cowan; Wei Zheng; Yan Zou; Xiujuan Shi; Jian Chen; Frank S Rosenthal; Qiyuan Fan Journal: Neurotoxicology Date: 2009-02-20 Impact factor: 4.294
Authors: Tomás R Guilarte; Neal C Burton; Tatyana Verina; Vinaykumar V Prabhu; Kevin G Becker; Tore Syversen; Jay S Schneider Journal: J Neurochem Date: 2008-02-13 Impact factor: 5.372