D C Gesink Law1, R F Maclehose, M P Longnecker. 1. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. dionne.gesinklaw@montana.edu
Abstract
BACKGROUND: Obesity may reduce fecundity. We examined the obesity-fecundity association in relation to menstrual cycle regularity, parity, smoking habits and age to gain insight into mechanisms and susceptible subgroups. METHODS: Data were provided by 7327 pregnant women enrolled in the Collaborative Perinatal Project at 12 study centres in the United States from 1959 to 1965. Prepregnancy body mass index (BMI) was analysed continuously and categorically [underweight (<18.5 kg/m2), optimal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) and obese (>or=30.0 kg/m2)]. Adjusted fecundability odds ratios (FORs) were estimated using Cox proportional hazards modelling for discrete time data. RESULTS: Fecundity was reduced for overweight [OR=0.92, 95% confidence interval (95% CI): 0.84, 1.01] and obese (OR=0.82, 95% CI: 0.72, 0.95) women compared with optimal weight women and was more evident for obese primiparous women (OR=0.66, 95% CI: 0.49, 0.89). Fecundity remained reduced for overweight and obese women with normal menstrual cycles. Neither smoking habits nor age modified the association. CONCLUSIONS: Obesity was associated with reduced fecundity for all subgroups of women and persisted for women with regular cycles. Our results suggest that weight loss could increase fecundity for overweight and obese women, regardless of menstrual cycle regularity, parity, smoking habits and age.
BACKGROUND: Obesity may reduce fecundity. We examined the obesity-fecundity association in relation to menstrual cycle regularity, parity, smoking habits and age to gain insight into mechanisms and susceptible subgroups. METHODS: Data were provided by 7327 pregnant women enrolled in the Collaborative Perinatal Project at 12 study centres in the United States from 1959 to 1965. Prepregnancy body mass index (BMI) was analysed continuously and categorically [underweight (<18.5 kg/m2), optimal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) and obese (>or=30.0 kg/m2)]. Adjusted fecundability odds ratios (FORs) were estimated using Cox proportional hazards modelling for discrete time data. RESULTS: Fecundity was reduced for overweight [OR=0.92, 95% confidence interval (95% CI): 0.84, 1.01] and obese (OR=0.82, 95% CI: 0.72, 0.95) women compared with optimal weight women and was more evident for obese primiparous women (OR=0.66, 95% CI: 0.49, 0.89). Fecundity remained reduced for overweight and obesewomen with normal menstrual cycles. Neither smoking habits nor age modified the association. CONCLUSIONS: Obesity was associated with reduced fecundity for all subgroups of women and persisted for women with regular cycles. Our results suggest that weight loss could increase fecundity for overweight and obesewomen, regardless of menstrual cycle regularity, parity, smoking habits and age.
Authors: D S Kiddy; D Hamilton-Fairley; A Bush; F Short; V Anyaoku; M J Reed; S Franks Journal: Clin Endocrinol (Oxf) Date: 1992-01 Impact factor: 3.478
Authors: Robert J Norman; Manny Noakes; Ruijin Wu; Michael J Davies; Lisa Moran; Jim X Wang Journal: Hum Reprod Update Date: 2004 May-Jun Impact factor: 15.610
Authors: S L Loy; Y B Cheung; S E Soh; S Ng; M T Tint; I M Aris; J Y Bernard; Y S Chong; K M Godfrey; L P Shek; K H Tan; Y S Lee; H H Tan; B S M Chern; N Lek; F Yap; S Y Chan; C Chi; J K Y Chan Journal: Hum Reprod Date: 2018-11-01 Impact factor: 6.918
Authors: N Santoro; S L Crawford; W L Lasley; J L Luborsky; K A Matthews; D McConnell; J F Randolph; E B Gold; G A Greendale; S G Korenman; L Powell; M F Sowers; G Weiss Journal: J Clin Endocrinol Metab Date: 2008-02-19 Impact factor: 5.958
Authors: Alex J Polotsky; Susan M Hailpern; Joan H Skurnick; Joan C Lo; Barbara Sternfeld; Nanette Santoro Journal: Fertil Steril Date: 2009-01-30 Impact factor: 7.329