Literature DB >> 17095218

Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry.

Matthew J Barnes1, Richard Conroy, David J Miller, John S Mills, John G Montana, Parminder K Pooni, Graham A Showell, Louise M Walsh, Julie B H Warneck.   

Abstract

The synthesis, physicochemical properties and pharmacological profiles of two novel silicon-containing p38 MAP kinase inhibitors are described.

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Year:  2006        PMID: 17095218     DOI: 10.1016/j.bmcl.2006.10.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

1.  Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.

Authors:  Jun Wang; Chunlong Ma; Yibing Wu; Robert A Lamb; Lawrence H Pinto; William F DeGrado
Journal:  J Am Chem Soc       Date:  2011-08-12       Impact factor: 15.419

2.  2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-N-oxide: the case of quorum sensing inhibitors.

Authors:  Truong Thanh Tung; Thang Nguyen Quoc
Journal:  RSC Med Chem       Date:  2021-09-08

3.  The photophysical properties of naphthalene bridged disilanes.

Authors:  Vipin B Kumar; Cassandra L Fleming; Sai Shruthi Murali; Paul A Hume; Nathaniel J L K Davis; Tilo Söhnel; Erin M Leitao
Journal:  RSC Adv       Date:  2021-06-16       Impact factor: 4.036

4.  Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles.

Authors:  Scott J Barraza; Scott E Denmark
Journal:  J Am Chem Soc       Date:  2018-05-15       Impact factor: 15.419

5.  Catalytic reduction of aryl trialkylammonium salts to aryl silanes and arenes.

Authors:  Alexander W Rand; John Montgomery
Journal:  Chem Sci       Date:  2019-04-26       Impact factor: 9.825

  5 in total

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