| Literature DB >> 17095215 |
Gilles D Tamagnan1, Eric Brenner, David Alagille, Julie K Staley, Colin Haile, Andrei Koren, Michelle Early, Ronald M Baldwin, Frank I Tarazi, Ross J Baldessarini, Nachwa Jarkas, Mark M Goodman, John P Seibyl.
Abstract
A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, selectivity, and kinetics of [123I]INER make it a promising agent for imaging NET in vivo by noninvasive SPECT imaging.Entities:
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Year: 2006 PMID： 17095215 PMCID： PMC1806685 DOI： 10.1016/j.bmcl.2006.10.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823