| Literature DB >> 17095211 |
Poonam Shukla1, Amar Bahadur Singh, Arvind Kumar Srivastava, Ram Pratap.
Abstract
A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6% in STZ models, respectively. The most potent compound 5 g exhibited glucose lowering of 26.7% in SLM and 22.6% in STZ models. A definite structure-activity relationship was observed while varying the nature as well as the position of the amine in ring B.Entities:
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Year: 2006 PMID： 17095211 DOI： 10.1016/j.bmcl.2006.10.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823