Tetsuji Fujita1, Katsuhiko Yanaga. 1. Department of Surgery, Jikei University School of Medicine, Tokyo, Japan. tetsu@jg8.so-net.ne.jp
Abstract
BACKGROUND: Although there is increasing evidence suggesting that the vagus nerve functions as a connector between the nervous and immune systems in animals, little is known about the role of the vagus nerve in postoperative acute phase response in humans. MATERIALS AND METHODS: The extent of fever and acute phase protein response and the production of inflammatory cytokine during the early postoperative period were compared among the patients who had undergone total gastrectomy including truncal vagotomy (n = 13), those having distal gastrectomy with division of vagal branches (n = 14), and the patients with vagal nerve preserving gastrectomy (n = 12). RESULTS: There was no significant difference in serum levels of C-reactive protein, alpha-1-antirypsin, and interleukin-6 among the three groups. Also, postoperative maximum body temperature was similar. CONCLUSIONS: Vagotomy did not influence acute phase response after gastric cancer surgery. A multipathway mechanism for acute phase response including the induction of fever is suggested.
BACKGROUND: Although there is increasing evidence suggesting that the vagus nerve functions as a connector between the nervous and immune systems in animals, little is known about the role of the vagus nerve in postoperative acute phase response in humans. MATERIALS AND METHODS: The extent of fever and acute phase protein response and the production of inflammatory cytokine during the early postoperative period were compared among the patients who had undergone total gastrectomy including truncal vagotomy (n = 13), those having distal gastrectomy with division of vagal branches (n = 14), and the patients with vagal nerve preserving gastrectomy (n = 12). RESULTS: There was no significant difference in serum levels of C-reactive protein, alpha-1-antirypsin, and interleukin-6 among the three groups. Also, postoperative maximum body temperature was similar. CONCLUSIONS: Vagotomy did not influence acute phase response after gastric cancer surgery. A multipathway mechanism for acute phase response including the induction of fever is suggested.
Authors: M K Hansen; K A O'Connor; L E Goehler; L R Watkins; S F Maier Journal: Am J Physiol Regul Integr Comp Physiol Date: 2001-04 Impact factor: 3.619
Authors: M K Hansen; K T Nguyen; M Fleshner; L E Goehler; R P Gaykema; S F Maier; L R Watkins Journal: Am J Physiol Regul Integr Comp Physiol Date: 2000-02 Impact factor: 3.619
Authors: David J van Westerloo; Ilona A J Giebelen; Sandrine Florquin; Joost Daalhuisen; Marco J Bruno; Alex F de Vos; Kevin J Tracey; Tom van der Poll Journal: J Infect Dis Date: 2005-05-10 Impact factor: 5.226