Literature DB >> 17092821

Dihydrofolate reductase and antifolate resistance in malaria.

W Sirawaraporn1.   

Abstract

The dihydrofolate reductase (DHFR, EC 1.5.1.3) domain of Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is an attractive target of two important antifolate antimalarials: pyrimethamine (Pyr) and cycloguanil (Cyc). Over recent years, knowledge of malarial DHFR and mechanism(s) of antifolate resistance have increased substantially. These observations have provided an important framework for better understanding the molecular basis of antifolate resistance in malaria. This article provides a brief review and update on molecular aspects relevant to antifolate resistance in malaria.

Entities:  

Year:  1998        PMID： 17092821     DOI： 10.1016/s1368-7646(98)80015-0

Source DB:  PubMed          Journal:  Drug Resist Updat        ISSN： 1368-7646            Impact factor:   18.500


  5 in total

Review 1.  Drug resistance and genetic mapping in Plasmodium falciparum.

Authors:  Karen Hayton; Xin-Zhuan Su
Journal:  Curr Genet       Date:  2008-09-18       Impact factor: 3.886

Review 2.  Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs.

Authors:  Bharath Srinivasan; Sam Tonddast-Navaei; Ambrish Roy; Hongyi Zhou; Jeffrey Skolnick
Journal:  Med Res Rev       Date:  2018-09-07       Impact factor: 12.944

3.  New Insights into Antimalarial Chemopreventive Activity of Antifolates.

Authors:  Chatpong Pethrak; Navaporn Posayapisit; Jutharat Pengon; Nattida Suwanakitti; Atiporn Saeung; Molnipha Shorum; Kittipat Aupalee; Kritsana Taai; Yongyuth Yuthavong; Sumalee Kamchonwongpaisan; Natapong Jupatanakul
Journal:  Antimicrob Agents Chemother       Date:  2021-12-20       Impact factor: 5.938

4.  Sulfadoxine-pyrimethamine resistance in the rodent malaria parasite Plasmodium chabaudi.

Authors:  Karen Hayton; Lisa C Ranford-Cartwright; David Walliker
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

5.  Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers.

Authors:  Donelly A van Schalkwyk; Rebekah Burrow; Gisela Henriques; Nahla B Gadalla; Khalid B Beshir; Christian Hasford; Stephen G Wright; Xavier C Ding; Peter L Chiodini; Colin J Sutherland
Journal:  Malar J       Date:  2013-09-13       Impact factor: 2.979
  5 in total

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