Literature DB >> 17092812

Nucleoside transport and its significance for anticancer drug resistance.

J R Mackey1, S A Baldwin, J D Young, C E Cass.   

Abstract

This article discusses the role of nucleoside transport processes in the cytotoxicity of clinically important anticancer nucleosides. This article summarizes recent advances in the molecular biology of nucleoside transport proteins, review the current state of knowledge of the transportability of therapeutically useful anticancer nucleosides, and provide an overview of the role of nucleoside transport deficiency as a mechanism of resistance to nucleoside cytotoxicity are summarized. Several strategies for utilization of nucleoside transport processes to improve the therapeutic index of anticancer therapies, including the use of nucleoside-transport inhibitors to modulate toxicity of both nucleoside and non-nucleoside antimetabolite drugs are also presented.

Entities:  

Year:  1998        PMID： 17092812     DOI： 10.1016/s1368-7646(98)80047-2

Source DB:  PubMed          Journal:  Drug Resist Updat        ISSN： 1368-7646            Impact factor:   18.500


  29 in total

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Journal:  World J Gastroenterol       Date:  2015-02-28       Impact factor: 5.742

Review 2.  Adjuvant pharmacotherapy in the management of elderly patients with pancreatic cancer.

Authors:  Raphaël Maréchal; Anne Demols; Jean-Luc Van Laethem
Journal:  Drugs Aging       Date:  2013-03       Impact factor: 3.923

3.  Quantitation of synergism of arabinosylcytosine and cladribine against the growth of arabinosylcytosine-resistant human lymphoid cells.

Authors:  Tieran Han; Marilyn Fernandez; Ting-Chao Chou; Ram P Agarwal
Journal:  J Cancer Res Clin Oncol       Date:  2005-10-20       Impact factor: 4.553

4.  Cysteine-accessibility analysis of transmembrane domains 11-13 of human concentrative nucleoside transporter 3.

Authors:  Jing Zhang; Tracey Tackaberry; Mabel W L Ritzel; Taylor Raborn; Gerry Barron; Stephen A Baldwin; James D Young; Carol E Cass
Journal:  Biochem J       Date:  2006-03-01       Impact factor: 3.857

5.  Impact of the 2'- and 3'-Sugar Hydroxyl Moieties on Gas-Phase Nucleoside Structure.

Authors:  L A Hamlow; Zachary J Devereaux; H A Roy; N A Cunningham; G Berden; J Oomens; M T Rodgers
Journal:  J Am Soc Mass Spectrom       Date:  2019-03-08       Impact factor: 3.109

6.  Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q).

Authors:  M F Vickers; R S Mani; M Sundaram; D L Hogue; J D Young; S A Baldwin; C E Cass
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

7.  Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2.

Authors:  S Y Yao; M Sundaram; E G Chomey; C E Cass; S A Baldwin; J D Young
Journal:  Biochem J       Date:  2001-01-15       Impact factor: 3.857

8.  Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.

Authors:  Erica J Carrier; John A Auchampach; Cecilia J Hillard
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-03       Impact factor: 11.205

9.  Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes.

Authors:  Kyla M Smith; Amy M L Ng; Sylvia Y M Yao; Kathy A Labedz; Edward E Knaus; Leonard I Wiebe; Carol E Cass; Stephen A Baldwin; Xing-Zhen Chen; Edward Karpinski; James D Young
Journal:  J Physiol       Date:  2004-06-11       Impact factor: 5.182

10.  Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor.

Authors:  Gregory I Liou; John A Auchampach; Cecilia J Hillard; Gu Zhu; Bilal Yousufzai; Salman Mian; Sohail Khan; Yousuf Khalifa
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-07-18       Impact factor: 4.799
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