OBJECTIVE: To morphometrically compare local atherosclerotic changes in cancerous prostate with those in noncancerous prostate specimens, as epidemiological studies report a positive association between the prevalence of general atherosclerosis and prostate cancer. MATERIALS AND METHODS: The intima-to-media-ratio (IMR) of 538 prostate capsular tissue arteries was measured in 50 prostate cancer-positive and 29 prostate cancer-negative specimens (including 26 with benign prostatic hyperplasia and three with normal prostatic tissue). RESULTS: An IMR of >1 was significantly associated with prostate cancer and a greater risk of prostate cancer (odds ratio 2.28). The IMR was >1 in cancer-positive specimens about twice as often as in cancer-negative tissue. CONCLUSION: Local atherosclerosis (measured by the IMR) was more pronounced in prostate cancer-positive than in prostate cancer-negative specimens. The results support the view that men with local atherosclerotic lesions are at higher risk of prostate cancer.
OBJECTIVE: To morphometrically compare local atherosclerotic changes in cancerous prostate with those in noncancerous prostate specimens, as epidemiological studies report a positive association between the prevalence of general atherosclerosis and prostate cancer. MATERIALS AND METHODS: The intima-to-media-ratio (IMR) of 538 prostate capsular tissue arteries was measured in 50 prostate cancer-positive and 29 prostate cancer-negative specimens (including 26 with benign prostatic hyperplasia and three with normal prostatic tissue). RESULTS: An IMR of >1 was significantly associated with prostate cancer and a greater risk of prostate cancer (odds ratio 2.28). The IMR was >1 in cancer-positive specimens about twice as often as in cancer-negative tissue. CONCLUSION: Local atherosclerosis (measured by the IMR) was more pronounced in prostate cancer-positive than in prostate cancer-negative specimens. The results support the view that men with local atherosclerotic lesions are at higher risk of prostate cancer.
Authors: Ronald M Summers; Daniel C Elton; Sungwon Lee; Yingying Zhu; Jiamin Liu; Mohammedhadi Bagheri; Veit Sandfort; Peter C Grayson; Nehal N Mehta; Peter A Pinto; W Marston Linehan; Alberto A Perez; Peter M Graffy; Stacy D O'Connor; Perry J Pickhardt Journal: Acad Radiol Date: 2020-09-18 Impact factor: 3.173
Authors: Martina Hager; Gregor Mikuz; Heike Haufe; Christian Kolbitsch; Katharina B Moser; Patrizia L Moser Journal: World J Urol Date: 2008-05-16 Impact factor: 4.226
Authors: Sungwon Lee; Daniel C Elton; James L Gulley; Perry J Pickhardt; William L Dahut; Ravi A Madan; Peter A Pinto; Deborah E Citrin; Ronald M Summers Journal: Tomography Date: 2022-03-01