Literature DB >> 1709154

Phase II study of pibenzimol in pancreatic cancer. A Southwest Oncology Group study.

E H Kraut1, T Fleming, M Segal, J A Neidhart, B C Behrens, J MacDonald.   

Abstract

Twenty-three patients with advanced pancreatic adenocarcinoma were treated with Pibenzimol utilizing a daily intravenous schedule for five days. There were no objective responses seen. The major toxicity was pancreatic with grade 3 hyperglycemia in eleven patients. Pibenzimol is inactive in patients with advanced pancreatic adenocarcinoma.

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Year:  1991        PMID： 1709154     DOI： 10.1007/bf00194556

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  4 in total

Review 1.  Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence.

Authors:  S A Latt; G Stetten; L A Juergens; H F Willard; C D Scher
Journal:  J Histochem Cytochem       Date:  1975-07       Impact factor: 2.479

2.  Condensation--inhibition by 33258-Hoechst of centromeric heterochromatin in prematurely condensed mouse chromosomes.

Authors:  M Marcus; K Sperling
Journal:  Exp Cell Res       Date:  1979-10-15       Impact factor: 3.905

3.  The pleiotropic effects of 33258-Hoechst on the cell cycle in Chinese hamster cells in vitro.

Authors:  J Hirschberg; U Lavi; R Goitein; M Marcus
Journal:  Exp Cell Res       Date:  1980-11       Impact factor: 3.905

4.  Pattern of condensation of mouse and Chinese hamster chromosomes in G2 and mitosis of 33258-Hoechst-treated cells.

Authors:  M Marcus; K Nielsén; R Goitein; A Gropp
Journal:  Exp Cell Res       Date:  1979-08       Impact factor: 3.905
  4 in total
  5 in total

1.  Selective permeabilization of cervical cancer cells to an ionic DNA-binding cytotoxin by activation of P2Y receptors.

Authors:  Maurish Bukhari; Han Deng; Noelle Jones; Zachary Towne; Craig D Woodworth; Damien S K Samways
Journal:  FEBS Lett       Date:  2015-05-01       Impact factor: 4.124

2.  Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.

Authors:  Madhuri Dasari; Sungmun Lee; Jay Sy; Dongin Kim; Seungjun Lee; Milton Brown; Michael Davis; Niren Murthy
Journal:  Org Lett       Date:  2010-08-06       Impact factor: 6.005

Review 3.  Imidazoles as potential anticancer agents.

Authors:  Imran Ali; Mohammad Nadeem Lone; Haasan Y Aboul-Enein
Journal:  Medchemcomm       Date:  2017-04-13       Impact factor: 3.597

4.  New insight into the molecular mechanisms of the biological effects of DNA minor groove binders.

Authors:  Xinbo Zhang; Siyu Crystal Zhang; Dejun Sun; Jiang Hu; Anil Wali; Harvey Pass; Felix Fernandez-Madrid; Michael R Harbut; Naimei Tang
Journal:  PLoS One       Date:  2011-10-05       Impact factor: 3.240

5.  KCa3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells.

Authors:  Maurish Bukhari; Han Deng; Darren Sipes; Marisa Ruane-Foster; Kayla Purdy; Craig D Woodworth; Shantanu Sur; Damien S K Samways
Journal:  J Biol Chem       Date:  2020-11-23       Impact factor: 5.157
  5 in total

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