Literature DB >> 17091434

Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens.

Vichai Reutrakul1, Waraporn Chanakul, Manat Pohmakotr, Thaworn Jaipetch, Chalobon Yoosook, Jittra Kasisit, Chanita Napaswat, Thawatchai Santisuk, Samran Prabpai, Palangpon Kongsaeree, Patoomratana Tuchinda.   

Abstract

Two new xanthones, 1,3,8-trihydroxy-2,4-dimethoxyxanthone (1) and 1,7-dihydroxy-2,8-dimethoxyxanthone (2), along with twelve known compounds 3 - 14 were isolated from leaves and twigs of Cratoxylum arborescens. Compound 1, euxanthone (4), betulinic acid (8), lup-20(29)-ene-3beta,30-diol (9), 3beta-hydroxylup-20(29)-en-30-oic acid (10) and 3,4-dihydroxybenzoic acid (11) displayed anti-HIV-1 activities in the syncytium assay using (Delta)(Tat/Rev)MC99 virus and the 1A2 cell line system (EC (50) values between 3.9 and 32.2 microg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8 - 10 inhibited HIV-1 reverse transcriptase with IC (50) values between 8.7 and 84.9 microg/mL.

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Year:  2006        PMID： 17091434     DOI： 10.1055/s-2006-951725

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

1.  The anti-tumor effect and biological activities of the extract JMM6 from the stem-barks of the Chinese Juglans mandshurica Maxim on human hepatoma cell line BEL-7402.

Authors:  Yongli Zhang; Yuqiang Cui; Jiayong Zhu; Hongzhi Li; Jianwen Mao; Xiaobao Jin; Xiangsheng Wang; Yifan Du; Jiazheng Lu
Journal:  Afr J Tradit Complement Altern Med       Date:  2012-12-31

Review 2.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

3.  1,3,6-Trihy-droxy-7-meth-oxy-2,8-bis-(3-methyl-but-2-en-yl)-9H-xanthen-9-one.

Authors:  Gwendoline Cheng Lian Ee; Wei Chung Sim; Huey Chong Kwong; Mohamed Ibrahim Mohamed Tahir; Sidik Silong
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-30

4.  α -Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study.

Authors:  Heyam M A Sidahmed; Siddig Ibrahim Abdelwahab; Syam Mohan; Mahmood Ameen Abdulla; Manal Mohamed Elhassan Taha; Najihah Mohd Hashim; A Hamid A Hadi; Jamunarani Vadivelu; Mun Loke Fai; Mawardi Rahmani; Maizatulakmal Yahayu
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-24       Impact factor: 2.629

5.  Quinones as key intermediates in natural products Synthesis. Syntheses of bioactive xanthones from Hypericum perforatum.

Authors:  George A Kraus; John Mengwasser
Journal:  Molecules       Date:  2009-08-03       Impact factor: 4.411

6.  Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2).

Authors:  Mohammad Firoz Khan; Nusrat Nahar; Ridwan Bin Rashid; Akhtaruzzaman Chowdhury; Mohammad A Rashid
Journal:  BMC Complement Altern Med       Date:  2018-02-02       Impact factor: 3.659

Review 7.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923

8.  Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense.

Authors:  Surat Laphookhieo; Wisanu Maneerat; Sorwaporn Koysomboon
Journal:  Molecules       Date:  2009-03-30       Impact factor: 4.411
  8 in total

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