Literature DB >> 17091337

Organization of the interferon-inducible 2',5'-oligoadenylate-dependent ribonuclease L (RNase L) gene of mouse.

Mitali Pandey1, Pramod C Rath.   

Abstract

Interferons (IFNs) induce a 2',5'-oligoadenylate (2-5A)-dependent ribonuclease L (RNase L) following virus-infection of mammalian cells. RNase L degrades both viral and cellular RNAs and restricts virus-proliferation. We have studied organization of RNase L gene in genomic DNA from the mouse liver by Southern blot analysis. Several BamHI, BglII, EcoRI, HincII, HindIII, NcoI, PstI, SacI, and XbaI restriction fragments hybridized to (32)P-labeled mouse RNase L cDNA and the 5'-proximal exon probes. Mouse RNase L gene exists as a single copy (>16 kb DNA) gene. A 5 kb HindIII and a 2.5 kb EcoRI DNA were detected as 5'-upstream DNA of the gene which may contain mouse RNase L promoter. Our results will help studying mouse RNase L gene promoter in further details.

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Year:  2006        PMID： 17091337     DOI： 10.1007/s11033-006-9020-z

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.742


  27 in total

1.  Synthesis and breakdown of pppA2'p5'A2'p5'A and transient inhibiton of protein synthesis in extracts from interferon-treated and control cells.

Authors:  B R Williams; I M Kerr; C S Gilbert; C N White; L A Ball
Journal:  Eur J Biochem       Date:  1978-12

Review 2.  The antiviral potentials of Mx proteins.

Authors:  J Pavlovic; P Staeheli
Journal:  J Interferon Res       Date:  1991-08

3.  A hybrid protein kinase-RNase in an interferon-induced pathway?

Authors:  P Bork; C Sander
Journal:  FEBS Lett       Date:  1993-11-15       Impact factor: 4.124

Review 4.  How cells respond to interferons.

Authors:  G R Stark; I M Kerr; B R Williams; R H Silverman; R D Schreiber
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

5.  Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L.

Authors:  A Zhou; J Paranjape; T L Brown; H Nie; S Naik; B Dong; A Chang; B Trapp; R Fairchild; C Colmenares; R H Silverman
Journal:  EMBO J       Date:  1997-11-03       Impact factor: 11.598

6.  RNase L dimerization in a mammalian two-hybrid system in response to 2',5'-oligoadenylates.

Authors:  S Naik; J M Paranjape; R H Silverman
Journal:  Nucleic Acids Res       Date:  1998-03-15       Impact factor: 16.971

Review 7.  Implications for RNase L in prostate cancer biology.

Authors:  Robert H Silverman
Journal:  Biochemistry       Date:  2003-02-25       Impact factor: 3.162

Review 8.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

Authors:  J E Darnell; I M Kerr; G R Stark
Journal:  Science       Date:  1994-06-03       Impact factor: 47.728

9.  DNA motifs associated with aberrant CpG island methylation.

Authors:  F Alex Feltus; Eva K Lee; Joseph F Costello; Christoph Plass; Paula M Vertino
Journal:  Genomics       Date:  2006-02-17       Impact factor: 5.736

10.  The RNase L inhibitor (RLI) is induced by double-stranded RNA.

Authors:  C Martinand; T Salehzada; M Silhol; B Lebleu; C Bisbal
Journal:  J Interferon Cytokine Res       Date:  1998-12       Impact factor: 2.607
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  2 in total

1.  IL-29 and IFN-α regulate the expression of MxA, 2',5'-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells.

Authors:  Yu Chai; Hai-Liang Huang; Dao-Jun Hu; Xin Luo; Qian-Shan Tao; Xiao-Ling Zhang; Sheng-Quan Zhang
Journal:  Mol Biol Rep       Date:  2010-03-23       Impact factor: 2.316

2.  Expression, purification and characterization of the interferon-inducible, antiviral and tumour-suppressor protein, human RNase L.

Authors:  Ankush Gupta; Pramod C Rath
Journal:  J Biosci       Date:  2012-03       Impact factor: 1.826
  2 in total

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