Literature DB >> 17090742

Assessment of adverse drug events among patients in a tertiary care medical center.

Philip E Johnston1, Daniel J France, Daniel W Byrne, Harvey J Murff, Byron Lee, Renee A Stiles, Theodore Speroff.   

Abstract

PURPOSE: Specific patient and clinical characteristics associated with an increased risk of sustaining an adverse event (AE) were identified.
METHODS: AE reports for patients in a 658-bed tertiary care medical center between January 1, 2000, and June 30, 2002, were analyzed. The data collected from each report included medical record number, patient sex, patient age, clinical service, date of occurrence, diagnoses, type of error, suspected medication, and severity of the AE. A three-stage logistic regression model with high-risk indicators was used to evaluate key indicators of the most vulnerable patient populations.
RESULTS: The number of control patients and those with AEs totaled 60,206. This population was then randomly split into two equal groups of patients: the training data set (n = 30,103) and the validation data set (n = 30,103). AEs occurred in a higher percentage of patients who were age <1 year, 1-15, 47-59, and > or =60 years than in other groups. A higher percentage of AEs were reported in men than women, but the groups were not significantly different when comparing those with an AE and those without an AE. Asian Indian patients demonstrated a high rate of AEs, but this may be a statistical artifact, reflecting their very small percentage in the study. Evaluation of admission sources revealed that doctors' offices, clinic referrals, and local hospital transfers accounted for higher rates of AEs than other sources.
CONCLUSION: Certain age groups, diagnoses, admission sources, types of insurance, and the use of specific medications or medication classes were associated with increased AE rates at a tertiary care medical center.

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Year:  2006        PMID: 17090742     DOI: 10.2146/ajhp050405

Source DB:  PubMed          Journal:  Am J Health Syst Pharm        ISSN: 1079-2082            Impact factor:   2.637


  4 in total

Review 1.  Factors affecting the development of adverse drug reactions (Review article).

Authors:  Muaed Jamal Alomar
Journal:  Saudi Pharm J       Date:  2013-02-24       Impact factor: 4.330

2.  Development of an adverse drug reaction risk assessment score among hospitalized patients with chronic kidney disease.

Authors:  Fatemeh Saheb Sharif-Askari; Syed Azhar Syed Sulaiman; Narjes Saheb Sharif-Askari; Ali Al Sayed Hussain
Journal:  PLoS One       Date:  2014-04-22       Impact factor: 3.240

Review 3.  Risk Factors Associated with the Requirement for Pharmaceutical Intervention in the Hospital Setting: A Systematic Review of the Literature.

Authors:  Emma Suggett; John Marriott
Journal:  Drugs Real World Outcomes       Date:  2016-09

4.  Computerized surveillance of opioid-related adverse drug events in perioperative care: a cross-sectional study.

Authors:  Julie A Eckstrand; Ashraf S Habib; Monica M Horvath; Abbie Williamson; Katherine G Gattis; Heidi Cozart; Jeffrey Ferranti
Journal:  Patient Saf Surg       Date:  2009-08-11
  4 in total

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