Literature DB >> 17089794

The Rta/Orf50 transactivator proteins of the gamma-herpesviridae.

M R Staudt1, D P Dittmer.   

Abstract

The replication and transcription activator protein, Rta, is encoded by Orf50 in Kaposi's sarcoma-associated herpesvirus (KSHV) and other known gammaherpesviruses including Epstein-Barr virus (EBV), rhesus rhadinovirus (RRV), herpesvirus saimiri (HVS), and murine herpesvirus 68 (MHV-68). Each Rta/Orf50 homologue of each gammaherpesvirus plays a pivotal role in the initiation of viral lytic gene expression and lytic reactivation from latency. Here we discuss the Rta/Orf50 of KSHV in comparison to the Rta/Orf50s of other gammaherpesviruses in an effort to identify structural motifs, mechanisms of action, and modulating host factors.

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Year:  2007        PMID： 17089794     DOI： 10.1007/978-3-540-34344-8_3

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  45 in total

1.  Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.

Authors:  Katharina Heinzelmann; Barbara A Scholz; Agnes Nowak; Even Fossum; Elisabeth Kremmer; Juergen Haas; Ronald Frank; Bettina Kempkes
Journal:  J Virol       Date:  2010-09-22       Impact factor: 5.103

2.  Amplification of JNK signaling is necessary to complete the murine gammaherpesvirus 68 lytic replication cycle.

Authors:  James A Stahl; Clinton R Paden; Shweta S Chavan; Veronica MacLeod; Ricky D Edmondson; Samuel H Speck; J Craig Forrest
Journal:  J Virol       Date:  2012-09-26       Impact factor: 5.103

3.  Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency.

Authors:  Amanda R Robinson; Swee Sen Kwek; Stacy R Hagemeier; Coral K Wille; Shannon C Kenney
Journal:  J Virol       Date:  2011-06-22       Impact factor: 5.103

4.  The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency.

Authors:  Kathleen S Gray; J Craig Forrest; Samuel H Speck
Journal:  J Virol       Date:  2010-03-03       Impact factor: 5.103

5.  Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity.

Authors:  Emi Sei; Nicholas K Conrad
Journal:  Virology       Date:  2011-09-01       Impact factor: 3.616

6.  Murine Gammaherpesvirus 68 ORF48 Is an RTA-Responsive Gene Product and Functions in both Viral Lytic Replication and Latency during In Vivo Infection.

Authors:  Jing Qi; Chuanhui Han; Danyang Gong; Ping Liu; Sheng Zhou; Hongyu Deng
Journal:  J Virol       Date:  2015-03-11       Impact factor: 5.103

7.  Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genes.

Authors:  Linda M Persson; Angus C Wilson
Journal:  J Virol       Date:  2009-11-11       Impact factor: 5.103

8.  Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways.

Authors:  Brooke B Sahin; Denish Patel; Nicholas K Conrad
Journal:  PLoS Pathog       Date:  2010-03-05       Impact factor: 6.823

9.  Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.

Authors:  Xiaonan Dong; Hao Feng; Qinmiao Sun; Haiyan Li; Ting-Ting Wu; Ren Sun; Scott A Tibbetts; Zhijian J Chen; Pinghui Feng
Journal:  PLoS Pathog       Date:  2010-07-29       Impact factor: 6.823

10.  Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element.

Authors:  Yunhua Liu; Yajun Cao; Deguang Liang; Yuan Gao; Tian Xia; Erle S Robertson; Ke Lan
Journal:  Virology       Date:  2008-09-10       Impact factor: 3.616
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