OBJECTIVE: To determine the effects of n3-PUFA supplementation, in the dose used in the GISSI-Prevenzione study, on indices of heart rate variability (HRV) in patients following myocardial infarction (AMI). MATERIALS AND METHODS: Open label randomised single blind controlled trial. Thirty eight patients post AMI, stable on standard secondary prevention drug therapy were single blind randomised to receive either Omacor 1 g/day (n = 21) or usual care (n = 17). HRV indices (time and frequency-domain) were measured at baseline and following 3 months of treatment. RESULTS: At baseline there were no significant differences in clinical, biochemical or HRV indices between patient groups. After 3 months therapy there were no observed changes in measured HRV indices in either the Omacor supplemented or 'usual care' groups. CONCLUSIONS: Three month supplementation of omega 3 PUFA (Omacor) 1 g/day has no effect on HRV is patients post AMI.
RCT Entities:
OBJECTIVE: To determine the effects of n3-PUFA supplementation, in the dose used in the GISSI-Prevenzione study, on indices of heart rate variability (HRV) in patients following myocardial infarction (AMI). MATERIALS AND METHODS: Open label randomised single blind controlled trial. Thirty eight patients post AMI, stable on standard secondary prevention drug therapy were single blind randomised to receive either Omacor 1 g/day (n = 21) or usual care (n = 17). HRV indices (time and frequency-domain) were measured at baseline and following 3 months of treatment. RESULTS: At baseline there were no significant differences in clinical, biochemical or HRV indices between patient groups. After 3 months therapy there were no observed changes in measured HRV indices in either the Omacor supplemented or 'usual care' groups. CONCLUSIONS: Three month supplementation of omega 3 PUFA (Omacor) 1 g/day has no effect on HRV is patients post AMI.
Authors: Matthew P Harbaugh; Stephen B Manuck; J Richard Jennings; Sarah M Conklin; Jeffrey K Yao; Matthew F Muldoon Journal: Int J Cardiol Date: 2012-06-16 Impact factor: 4.164
Authors: Katherine A Sauder; Ann C Skulas-Ray; Tavis S Campbell; Jillian A Johnson; Penny M Kris-Etherton; Sheila G West Journal: Psychosom Med Date: 2013-04-16 Impact factor: 4.312
Authors: George E Billman; Yoshinori Nishijima; Andriy E Belevych; Dmitry Terentyev; Ying Xu; Kaylan M Haizlip; Michelle M Monasky; Nitisha Hiranandani; William S Harris; Sandor Gyorke; Cynthia A Carnes; Paul M L Janssen Journal: Am J Physiol Heart Circ Physiol Date: 2010-01-22 Impact factor: 4.733