C-L Wang1, X-Y Tang, W-Q Chen, Y-X Su, C-X Zhang, Y-M Chen. 1. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.
Abstract
INTRODUCTION AND HYPOTHESIS: A large number studies have examined the association between estrogen receptor alpha (ESR-alpha) gene polymorphisms and bone mineral density (BMD) in the Chinese population. We conducted a meta-analysis to assess their pooled effects. METHODS: We searched for all published articles indexed in MEDLINE, the Chinese Biomedical Database, and the Chinese Journal Full-text Database from January 1994 to April 2006. Any cross-sectional study that tested the association between ESR-alpha PvuII or XbaI genotypes and BMD at the femoral neck or spine in Chinese women was included in the review. Data were extracted independently by two reviewers using a standardized data extraction form. Sixteen eligible studies involving 4,297 Chinese women were identified. RESULTS: The overall frequencies of X and P alleles were 28% and 40%, respectively. The PvuII polymorphism was statistically significantly associated with BMD at the femoral neck (P = 0.038 for PP = Pp = pp) but not at the lumbar spine in all women. The BMD difference for the contrasts of PP versus Pp/pp genotypes was -0.0105 (95%CI, -0.0202 approximately -0.0008) g/cm(2) (P = 0.036). The XbaI polymorphism was not associated with BMD at the femoral neck or lumbar spine. CONCLUSION: The PvuII polymorphism had a very weak association with femoral neck BMD whereas XbaI polymorphism was unlikely to be a predictor of femoral neck or spine BMD in Chinese women.
INTRODUCTION AND HYPOTHESIS: A large number studies have examined the association between estrogen receptor alpha (ESR-alpha) gene polymorphisms and bone mineral density (BMD) in the Chinese population. We conducted a meta-analysis to assess their pooled effects. METHODS: We searched for all published articles indexed in MEDLINE, the Chinese Biomedical Database, and the Chinese Journal Full-text Database from January 1994 to April 2006. Any cross-sectional study that tested the association between ESR-alpha PvuII or XbaI genotypes and BMD at the femoral neck or spine in Chinese women was included in the review. Data were extracted independently by two reviewers using a standardized data extraction form. Sixteen eligible studies involving 4,297 Chinese women were identified. RESULTS: The overall frequencies of X and P alleles were 28% and 40%, respectively. The PvuII polymorphism was statistically significantly associated with BMD at the femoral neck (P = 0.038 for PP = Pp = pp) but not at the lumbar spine in all women. The BMD difference for the contrasts of PP versus Pp/pp genotypes was -0.0105 (95%CI, -0.0202 approximately -0.0008) g/cm(2) (P = 0.036). The XbaI polymorphism was not associated with BMD at the femoral neck or lumbar spine. CONCLUSION: The PvuII polymorphism had a very weak association with femoral neck BMD whereas XbaI polymorphism was unlikely to be a predictor of femoral neck or spine BMD in Chinese women.
Authors: E M Colin; A G Uitterlinden; J B J Meurs; A P Bergink; M van de Klift; Y Fang; P P Arp; A Hofman; J P T M van Leeuwen; H A P Pols Journal: J Clin Endocrinol Metab Date: 2003-08 Impact factor: 5.958
Authors: L Chailurkit; S Chanprasertyothin; S Charoenkiatkul; N Krisnamara; R Rajatanavin; B Ongphiphadhanakul Journal: J Nutr Health Aging Date: 2012-03 Impact factor: 4.075
Authors: Jian Min; Pengcheng Wang; Sathish Srinivasan; Jerome C Nwachukwu; Pu Guo; Minjian Huang; Kathryn E Carlson; John A Katzenellenbogen; Kendall W Nettles; Hai-Bing Zhou Journal: J Med Chem Date: 2013-04-15 Impact factor: 7.446
Authors: Daniel L Hertz; N Lynn Henry; Kelley M Kidwell; Dafydd Thomas; Audrey Goddard; Faouzi Azzouz; Kelly Speth; Lang Li; Mousumi Banerjee; Jacklyn N Thibert; Celina G Kleer; Vered Stearns; Daniel F Hayes; Todd C Skaar; James M Rae Journal: Physiol Genomics Date: 2016-08-19 Impact factor: 3.107
Authors: Gul Zaman; Leanne K Saxon; Andrew Sunters; Helen Hilton; Peter Underhill; Debbie Williams; Joanna S Price; Lance E Lanyon Journal: Bone Date: 2009-10-24 Impact factor: 4.398