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Literature DB >> 17088494

Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds.

Nguyen Tien Huy¹, Dinh Thanh Uyen, Atsushi Maeda, Dai Thi Xuan Trang, Tatsuo Oida, Shigeharu Harada, Kaeko Kamei.

Abstract

Current assays for screening new antimalarials need initiators of beta-hematin formation that require laborious preparation, special devices, and substrates. In this study, based on reduction of heme absorption in beta-hematin formation, we developed a simple colorimetric assay using Tween 20 as an initiator and a microplate reader for high-throughput screening of inhibitors of beta-hematin formation.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 17088494 PMCID： PMC1797674 DOI： 10.1128/AAC.00985-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

27 in total

1. Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores.

Authors: Y Kurosawa; A Dorn; M Kitsuji-Shirane; H Shimada; T Satoh; H Matile; W Hofheinz; R Masciadri; M Kansy; R G Ridley
Journal: Antimicrob Agents Chemother Date: 2000-10 Impact factor: 5.191

2. Neutralization of toxic heme by Plasmodium falciparum histidine-rich protein 2.

Authors: Nguyen Tien Huy; Satoshi Serada; Dai Thi Xuan Trang; Ryo Takano; Yoshiro Kondo; Kenji Kanaori; Kunihiko Tajima; Saburo Hara; Kaeko Kamei
Journal: J Biochem Date: 2003-05 Impact factor: 3.387

3. A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds.

Authors: E Deharo; R N García; P Oporto; A Gimenez; M Sauvain; V Jullian; H Ginsburg
Journal: Exp Parasitol Date: 2002-04 Impact factor: 2.011

4. A simple and rapid colorimetric method to measure hemozoin crystal growth in vitro.

Authors: Nguyen Tien Huy; Dinh Thanh Uyen; Motohiro Sasai; Dai Thi Xuan Trang; Takeshi Shiono; Shigeharu Harada; Kaeko Kamei
Journal: Anal Biochem Date: 2005-08-25 Impact factor: 3.365

5. Membrane proteins. Detergent ringing true as a model for membranes.

Authors: J Barber
Journal: Nature Date: 1989-08-24 Impact factor: 49.962

Review 6. Theories on malarial pigment formation and quinoline action.

Authors: David J Sullivan
Journal: Int J Parasitol Date: 2002-12-04 Impact factor: 3.981

7. Clotrimazole binds to heme and enhances heme-dependent hemolysis: proposed antimalarial mechanism of clotrimazole.

Authors: Nguyen Tien Huy; Kaeko Kamei; Takushi Yamamoto; Yoshiro Kondo; Kenji Kanaori; Ryo Takano; Kunihiko Tajima; Saburo Hara
Journal: J Biol Chem Date: 2001-11-13 Impact factor: 5.157

8. Host heme catabolism in drug-sensitive and drug-resistant malaria.

Authors: J R Eckman; S Modler; J W Eaton; E Berger; R R Engel
Journal: J Lab Clin Med Date: 1977-10

9. Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay.

Authors: Abhai K Tripathi; Shabana I Khan; Larry A Walker; Babu L Tekwani
Journal: Anal Biochem Date: 2004-02-01 Impact factor: 3.365

10. Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery.

Authors: Curtis Robert Chong; David Joseph Sullivan
Journal: Biochem Pharmacol Date: 2003-12-01 Impact factor: 5.858

18 in total

1. Lipophilic mediated assays for beta-hematin inhibitors.

Authors: Melissa D Carter; Vanessa V Phelan; Rebecca D Sandlin; Brian O Bachmann; David W Wright
Journal: Comb Chem High Throughput Screen Date: 2010-03 Impact factor: 1.339

2. G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets.

Authors: Lynne M Harris; Katelyn R Monsell; Florian Noulin; M Toyin Famodimu; Nicolas Smargiasso; Christian Damblon; Paul Horrocks; Catherine J Merrick
Journal: Antimicrob Agents Chemother Date: 2018-02-23 Impact factor: 5.191

3. 2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.

Authors: Nguyen Tien Huy; Keisuke Mizunuma; Kirandeep Kaur; Nguyen Thanh Thuy Nhien; Meenakshi Jain; Dinh Thanh Uyen; Shigeharu Harada; Rahul Jain; Kaeko Kamei
Journal: Antimicrob Agents Chemother Date: 2007-06-11 Impact factor: 5.191

4. High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties.

Authors: Nguyen Tien Huy; Pham Lan Chi; Jun Nagai; Tran Ngoc Dang; Evaristus Chibunna Mbanefo; Ali Mahmoud Ahmed; Nguyen Phuoc Long; Le Thi Bich Thoa; Le Phi Hung; Afaf Titouna; Kaeko Kamei; Hiroshi Ueda; Kenji Hirayama
Journal: Antimicrob Agents Chemother Date: 2017-01-24 Impact factor: 5.191

5. Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties.

Authors: Farhana Mosaddeque; Shusaku Mizukami; Mohamed Gomaa Kamel; Awet Alem Teklemichael; Truong Van Dat; Satoshi Mizuta; Dinh Van Toan; Ali Mahmoud Ahmed; Nguyen Lam Vuong; Mohamed Tamer Elhady; Hoang Thi Nam Giang; Tran Ngoc Dang; Michiko Fukuda; Lam K Huynh; Yoshimasa Tanaka; Timothy J Egan; Osamu Kaneko; Nguyen Tien Huy; Kenji Hirayama
Journal: Antimicrob Agents Chemother Date: 2018-04-26 Impact factor: 5.191

10. Effect of Inducers, Incubation Time and Heme Concentration on IC(50) Value Variation in Anti-heme Crystallization Assay.

Authors: Nguyen Thanh Thuy Nhien; Nguyen Tien Huy; Dinh Thanh Uyen; Eric Deharo; Pham Thi Le Hoa; Kenji Hirayama; Shigeharu Harada; Kaeko Kamei
Journal: Trop Med Health Date: 2011-12-21