Literature DB >> 17088480

Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.

Wengang Yang1, Yongnian Sun, Avinash Phadke, Milind Deshpande, Mingjun Huang.   

Abstract

Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.

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Year:  2006        PMID： 17088480      PMCID： PMC1797658          DOI： 10.1128/AAC.00498-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Cell-free replication of the hepatitis C virus subgenomic replicon.

Authors:  Naushad Ali; Keith D Tardif; Aleem Siddiqui
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

2.  Quantitative analysis of the hepatitis C virus replication complex.

Authors:  Doris Quinkert; Ralf Bartenschlager; Volker Lohmann
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

3.  In vitro RNA replication directed by replicase complexes isolated from the subgenomic replicon cells of hepatitis C virus.

Authors:  Vicky C H Lai; Shannon Dempsey; Johnson Y N Lau; Zhi Hong; Weidong Zhong
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

4.  Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells.

Authors:  Richard W Hardy; Joseph Marcotrigiano; Keril J Blight; John E Majors; Charles M Rice
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

5.  Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Authors:  Stefania Di Marco; Cinzia Volpari; Licia Tomei; Sergio Altamura; Steven Harper; Frank Narjes; Uwe Koch; Michael Rowley; Raffaele De Francesco; Giovanni Migliaccio; Andrea Carfí
Journal:  J Biol Chem       Date:  2005-06-13       Impact factor: 5.157

6.  Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

Authors:  Han Ma; Vincent Leveque; Anniek De Witte; Weixing Li; Than Hendricks; Saundra M Clausen; Nick Cammack; Klaus Klumpp
Journal:  Virology       Date:  2005-02-05       Impact factor: 3.616

7.  The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.

Authors:  Klaus Klumpp; Vincent Lévêque; Sophie Le Pogam; Han Ma; Wen-Rong Jiang; Hyunsoon Kang; Caroline Granycome; Margaret Singer; Carl Laxton; Julie Qi Hang; Keshab Sarma; David B Smith; Dieter Heindl; Chris J Hobbs; John H Merrett; Julian Symons; Nick Cammack; Joseph A Martin; Rene Devos; Isabel Nájera
Journal:  J Biol Chem       Date:  2005-11-29       Impact factor: 5.157

8.  Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Authors:  Dashyant Dhanak; Kevin J Duffy; Victor K Johnston; Juili Lin-Goerke; Michael Darcy; Antony N Shaw; Baohua Gu; Carol Silverman; Adam T Gates; Michael R Nonnemacher; David L Earnshaw; David J Casper; Arun Kaura; Audrey Baker; Cathy Greenwood; Lester L Gutshall; Derrick Maley; Alfred DelVecchio; Ricardo Macarron; Glenn A Hofmann; Zaid Alnoah; Hung-Yuan Cheng; George Chan; Sanjay Khandekar; Richard M Keenan; Robert T Sarisky
Journal:  J Biol Chem       Date:  2002-08-06       Impact factor: 5.157

9.  Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft.

Authors:  Lu Gao; Hideki Aizaki; Jian-Wen He; Michael M C Lai
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

10.  Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Authors:  Pierre L Beaulieu; Michael Bös; Yves Bousquet; Patrick DeRoy; Gulrez Fazal; Jean Gauthier; James Gillard; Sylvie Goulet; Ginette McKercher; Marc-André Poupart; Serge Valois; George Kukolj
Journal:  Bioorg Med Chem Lett       Date:  2004-02-23       Impact factor: 2.823
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  1 in total

1.  ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication by altering the composition of viral replication complexes.

Authors:  Wengang Yang; Yongnian Sun; Xiaohong Hou; Yongsen Zhao; Joanne Fabrycki; Dawei Chen; Xiangzhu Wang; Atul Agarwal; Avinash Phadke; Milind Deshpande; Mingjun Huang
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191
  1 in total

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