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Literature DB >> 17088343

Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation.

Joshua D Hall¹, Robin R Craven, James R Fuller, Raymond J Pickles, Thomas H Kawula.

Abstract

Francisella tularensis replicates in macrophages and dendritic cells, but interactions with other cell types have not been well described. F. tularensis LVS invaded and replicated within alveolar epithelial cell lines. Following intranasal inoculation of C57BL/6 mice, Francisella localized to the alveolus and replicated within alveolar type II epithelial cells.

Entities: Species

Mesh：

Year: 2006 PMID： 17088343 PMCID： PMC1828526 DOI： 10.1128/IAI.01254-06

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

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Authors: Brittany L Mortensen; James R Fuller; Sharon Taft-Benz; Todd M Kijek; Cheryl N Miller; Max T H Huang; Thomas H Kawula
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2. Francisella tularensis reveals a disparity between human and mouse NLRP3 inflammasome activation.

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7. Temporal transcriptional response during infection of type II alveolar epithelial cells with Francisella tularensis live vaccine strain (LVS) supports a general host suppression and bacterial uptake by macropinocytosis.

Authors: Christopher E Bradburne; Anne B Verhoeven; Ganiraju C Manyam; Saira A Chaudhry; Eddie L Chang; Dzung C Thach; Charles L Bailey; Monique L van Hoek
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