Literature DB >> 17088207

Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

Anastassios V Tzingounis1, Roger A Nicoll.   

Abstract

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.

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Year:  2006        PMID： 17088207     DOI： 10.1016/j.neuron.2006.10.016

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  101 in total

Review 1.  New views of Arc, a master regulator of synaptic plasticity.

Authors:  Jason D Shepherd; Mark F Bear
Journal:  Nat Neurosci       Date:  2011-01-30       Impact factor: 24.884

2.  Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.

Authors:  Michael A Balamotis; Nele Tamberg; Young Jae Woo; Jingchuan Li; Brian Davy; Terumi Kohwi-Shigematsu; Yoshinori Kohwi
Journal:  Mol Cell Biol       Date:  2011-11-07       Impact factor: 4.272

Review 3.  Arc in synaptic plasticity: from gene to behavior.

Authors:  Erica Korb; Steven Finkbeiner
Journal:  Trends Neurosci       Date:  2011-09-30       Impact factor: 13.837

4.  A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease.

Authors:  Sara Landgren; Malin von Otter; Mona Seibt Palmér; Caroline Zetterström; Staffan Nilsson; Ingmar Skoog; Deborah R Gustafson; Lennart Minthon; Anders Wallin; Niels Andreasen; Nenad Bogdanovic; Jan Marcusson; Kaj Blennow; Henrik Zetterberg; Petronella Kettunen
Journal:  J Neural Transm (Vienna)       Date:  2012-05-25       Impact factor: 3.575

5.  Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia.

Authors:  Yong Chen; Sookhee Bang; Mary F McMullen; Hala Kazi; Konrad Talbot; Mei-Xuan Ho; Greg Carlson; Steven E Arnold; Wei-Yi Ong; Sangwon F Kim
Journal:  Mol Neurobiol       Date:  2016-02-12       Impact factor: 5.590

6.  Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

Authors:  Youn Na; Sungjin Park; Changhee Lee; Dong-Kyu Kim; Joo Min Park; Shanthini Sockanathan; Richard L Huganir; Paul F Worley
Journal:  Neuron       Date:  2016-07-07       Impact factor: 17.173

7.  Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neurons.

Authors:  P J Clark; T K Bhattacharya; D S Miller; J S Rhodes
Journal:  Neuroscience       Date:  2011-04-07       Impact factor: 3.590

8.  Activity-dependent Signaling and Epigenetic Abnormalities in Mice Exposed to Postnatal Ethanol.

Authors:  Shivakumar Subbanna; Vikram Joshi; Balapal S Basavarajappa
Journal:  Neuroscience       Date:  2018-07-20       Impact factor: 3.590

9.  The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice.

Authors:  R H Bonow; S Aïd; Y Zhang; K G Becker; F Bosetti
Journal:  Pharmacogenomics J       Date:  2008-10-28       Impact factor: 3.550

10.  PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats.

Authors:  Edward G Meloni; Karen T Kaye; Archana Venkataraman; William A Carlezon
Journal:  Neurobiol Learn Mem       Date:  2018-11-17       Impact factor: 2.877
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