| Literature DB >> 17088069 |
Simona Collina1, Guya Loddo, Mariangela Urbano, Laura Linati, Athos Callegari, Francesco Ortuso, Stefano Alcaro, Christian Laggner, Thierry Langer, Orazio Prezzavento, Giuseppe Ronsisvalle, Ornella Azzolina.
Abstract
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.Entities:
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Year: 2006 PMID： 17088069 DOI： 10.1016/j.bmc.2006.10.048
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641