| Literature DB >> 17088058 |
Anthony B Pinkerton1, Dehua Huang, Rowena V Cube, John H Hutchinson, Mary Struthers, Julia M Ayala, Pasquale P Vicario, Sima R Patel, Thomas Wisniewski, Julie A DeMartino, Jean-Michel Vernier.
Abstract
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).Entities:
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Year: 2006 PMID： 17088058 DOI： 10.1016/j.bmcl.2006.10.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823