BACKGROUND & AIMS: Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease. METHODS: Eight single-nucleotide polymorphisms (SNPs) were selected to tag common haplotypes from the 35-kb 3' region of MYO9B. These included the strongest celiac disease-associated variants reported in a Dutch cohort. These SNPs were studied in 3 independently collected and genotyped case-control cohorts of European descent (UK, Dutch, and Canadian/Italian), comprising in total 2717 inflammatory bowel disease patients (1197 with Crohn's disease, 1520 with ulcerative colitis) and 4440 controls. RESULTS: Common variation in MYO9B was associated with susceptibility to inflammatory bowel disease in all 3 cohorts examined (most associated SNP, rs1545620; meta-analysis P = 1.9 x 10(-6); odds ratio, 1.2), with the same alleles showing association as reported for celiac disease. CONCLUSIONS: MYO9B genetic variants predispose to inflammatory bowel disease. Interestingly, rs1545620 is a nonsynonymous variant leading to an amino acid change (Ala1011Ser) in the third calmodulin binding IQ domain of MYO9B. Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. These data imply shared causal mechanisms underlying intestinal inflammatory diseases.
BACKGROUND & AIMS: Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease. METHODS: Eight single-nucleotide polymorphisms (SNPs) were selected to tag common haplotypes from the 35-kb 3' region of MYO9B. These included the strongest celiac disease-associated variants reported in a Dutch cohort. These SNPs were studied in 3 independently collected and genotyped case-control cohorts of European descent (UK, Dutch, and Canadian/Italian), comprising in total 2717 inflammatory bowel disease patients (1197 with Crohn's disease, 1520 with ulcerative colitis) and 4440 controls. RESULTS: Common variation in MYO9B was associated with susceptibility to inflammatory bowel disease in all 3 cohorts examined (most associated SNP, rs1545620; meta-analysis P = 1.9 x 10(-6); odds ratio, 1.2), with the same alleles showing association as reported for celiac disease. CONCLUSIONS: MYO9B genetic variants predispose to inflammatory bowel disease. Interestingly, rs1545620 is a nonsynonymous variant leading to an amino acid change (Ala1011Ser) in the third calmodulin binding IQ domain of MYO9B. Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. These data imply shared causal mechanisms underlying intestinal inflammatory diseases.
Authors: C Núñez; J Oliver; J L Mendoza; M Gómez-García; A Piñero; C Taxonera; M Díaz-Rubio; M A López-Nevot; E G de la Concha; A Nieto; E Urcelay; A Martínez; J Martín Journal: Gut Date: 2007-09 Impact factor: 23.059
Authors: P Goyette; C Lefebvre; A Ng; S R Brant; J H Cho; R H Duerr; M S Silverberg; K D Taylor; A Latiano; G Aumais; C Deslandres; G Jobin; V Annese; M J Daly; R J Xavier; J D Rioux Journal: Mucosal Immunol Date: 2008-01-16 Impact factor: 7.313
Authors: Anu Kemppinen; Minna Suvela; Pentti J Tienari; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Ilkka Rautakorpi; Jan Hillert; Frida Lundmark; Annette Oturai; Lars Ryder; Hanne F Harbo; Elisabeth G Celius; Aarno Palotie; Mark Daly; Leena Peltonen; Janna Saarela Journal: Eur J Hum Genet Date: 2009-01-14 Impact factor: 4.246
Authors: Anna Latiano; Orazio Palmieri; Maria Rosa Valvano; Renata D'Incà; Salvatore Cucchiara; Gabriele Riegler; Anna Maria Staiano; Sandro Ardizzone; Salvatore Accomando; Gian Luigi de Angelis; Giuseppe Corritore; Fabrizio Bossa; Vito Annese Journal: World J Gastroenterol Date: 2008-08-07 Impact factor: 5.742
Authors: E A M Festen; P Goyette; R Scott; V Annese; A Zhernakova; J Lian; C Lefèbvre; S R Brant; J H Cho; M S Silverberg; K D Taylor; D J de Jong; P C Stokkers; D Mcgovern; O Palmieri; J-P Achkar; R J Xavier; M J Daly; R H Duerr; C Wijmenga; R K Weersma; J D Rioux Journal: Gut Date: 2009-02-06 Impact factor: 23.059