Literature DB >> 17087926

O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a.

Joanna Kubler-Kielb1, Evgeny Vinogradov, Chiayung Chu, Rachel Schneerson.   

Abstract

Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. [structure: see text]

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Year:  2006        PMID： 17087926      PMCID： PMC1885374          DOI： 10.1016/j.carres.2006.09.017

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  17 in total

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Authors:  Justen H Passwell; Shai Ashkenazi; Efrat Harlev; Dan Miron; Reut Ramon; Nahid Farzam; Liat Lerner-Geva; Yonit Levi; Chiayung Chu; Joseph Shiloach; John B Robbins; Rachel Schneerson
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6.  Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease.

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10.  Effect of O acetylation of Neisseria meningitidis serogroup A capsular polysaccharide on development of functional immune responses.

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  17 in total

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Review 2.  Progress and pitfalls in Shigella vaccine research.

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3.  Identification of an O-acyltransferase gene (oacB) that mediates 3- and 4-O-acetylation of rhamnose III in Shigella flexneri O antigens.

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5.  Immunochemical studies of Shigella flexneri 2a and 6, and Shigella dysenteriae type 1 O-specific polysaccharide-core fragments and their protein conjugates as vaccine candidates.

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6.  Serotype-converting bacteriophage SfII encodes an acyltransferase protein that mediates 6-O-acetylation of GlcNAc in Shigella flexneri O-antigens, conferring on the host a novel O-antigen epitope.

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7.  Serological identification and prevalence of a novel O-antigen epitope linked to 3- and 4-O-acetylated rhamnose III of lipopolysaccharide in Shigella flexneri.

Authors:  Jianping Wang; Ruiting Lan; Yuriy A Knirel; Xia Luo; Sof'ya N Senchenkova; Alexander S Shashkov; Jianguo Xu; Qiangzheng Sun
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9.  Influence of Shigella flexneri 2a O Antigen Acetylation on Its Bacteriophage Sf6 Receptor Activity and Bacterial Interaction with Human Cells.

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10.  Escherichia coli K1-specific bacteriophage CUS-3 distribution and function in phase-variable capsular polysialic acid O acetylation.

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