OBJECTIVE: To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research. METHOD: Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R. These subjects were recruited from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), using the Composite International Diagnostic Interview. Determinants for persistence were transformed into a practical risk score using proportional hazards models and bootstrapping techniques. RESULTS: The risk of MDE persistence after 12 months was 23%. The score comprised measures of physical illness, social support, depression severity and recurrency, and duration of previous episodes. With increasing categories of these measures, the predicted risks increased from 7 to 40%. CONCLUSION: We constructed the Persistence of Depression Score (PDS) showing reasonable performance. The PDS could be of importance in clinical practice to support treatment decisions.
OBJECTIVE: To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research. METHOD: Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R. These subjects were recruited from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), using the Composite International Diagnostic Interview. Determinants for persistence were transformed into a practical risk score using proportional hazards models and bootstrapping techniques. RESULTS: The risk of MDE persistence after 12 months was 23%. The score comprised measures of physical illness, social support, depression severity and recurrency, and duration of previous episodes. With increasing categories of these measures, the predicted risks increased from 7 to 40%. CONCLUSION: We constructed the Persistence of Depression Score (PDS) showing reasonable performance. The PDS could be of importance in clinical practice to support treatment decisions.
Authors: Marc H Jansen; Sophie E Veldhuijzen van Zanten; Esther Sanchez Aliaga; Martijn W Heymans; Monika Warmuth-Metz; Darren Hargrave; Erica J van der Hoeven; Corrie E Gidding; Eveline S de Bont; Omid S Eshghi; Roel Reddingius; Cacha M Peeters; Antoinette Y N Schouten-van Meeteren; Rob H J Gooskens; Bernd Granzen; Gabriel M Paardekooper; Geert O Janssens; David P Noske; Frederik Barkhof; Christof M Kramm; W Peter Vandertop; Gertjan J Kaspers; Dannis G van Vuurden Journal: Neuro Oncol Date: 2014-06-05 Impact factor: 12.300
Authors: Claudia M Klier; Katherine L Rosenblum; Maria Zeller; Kornelia Steinhardt; Niels Bergemann; Maria Muzik Journal: Depress Anxiety Date: 2008 Impact factor: 6.505